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VEGF CD 62P和PMA与SLE患者易栓状态关系研究 |
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【摘要】 目的 观察系统性红斑狼疮(SLE)患者血管新生、血小板活化因子的临床意义。方法 用流式细胞术测定血小板CD 62P、血小板单核细胞聚合体(PMA),ELISA法测定血管内皮细胞生长因子(VEGF)。结果 SLE活动期VEGF、血小板及炎症细胞的活化水平明显增高(P<0.05),稳定期该类因子已基本恢复正常水平(P>0.05)。SLE患者治疗后VEGF、血小板及炎症细胞的活化程度抑制,与治疗前相比有显著差异(P<0.05)。结论 SLE 患者处于血栓前状态,易 于发生动静脉血栓事件,早期发现临床征象可以及时干预治疗,改善预后。
【关键词】 系统性红斑狼疮; 易栓症; 血管内皮细胞生长因子(VEGF); 血小板表面CD 62p; 血小板单核细胞聚合体(PMA)
Research on the Relationship of VEGF, CD 62p and PlateletMonocyte Aggregation (PMA)in Patients with Systemic Lupus Erythematosus
HE Bin,GU Jian,SHI Jian xia,SUN Mei,ZHANG Yu.
( The Clinical Medical College of Yangzhou University ,Yangzhou 225000,China)
Abstract: Objective To investigate the significance of vascular endothelial growth factor (VEGF) and platelet activation factor in patients with systemic lupus erythematosus.Methods CD 62p and plateletmonocyte aggregation (PMA)were detected using flow cytometry,VEGF was detected by enzymelinked immunosorbent assay (ELISA) .Results In patients with systemic lupus erythematosus, the level of VEGF and platelet activation factor is stepped up in active stage(P<0.05),these factors were nearly normal in stable phase(P>0.05),[1] [2] [3] [4] [5] 下一页 上一个医学论文: 急性脑梗死患者中性粒细胞活化的研究 下一个医学论文: 老年内科患者血栓前状态的调查及诊断标准的探讨
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