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对老年恶性肿瘤患者合并医院内真菌感染调查 |
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sp;infection took place more frequently in respiratory tract, oral cavity and intestinal tract. Single variable analysis screened out the relative factors as the duration in hospital, primary diseases, age, PS score, neutropenia and antibiotic administration. Multiple Logistic regression analysis showed the most important risk factors of hospital acquired fungal infection were the duration in hospital, age, PS score, neutropenia, antibiotic administration and primary diseases. Conclusions The main risk factors of hospital acquired fungal infection in elderly patients with malignant tumor are the duration in hospital, age, PS score, neutropenia, primary diseases and antibiotic administration. The principal infection agents may play a crucial role in the development of hospital acquired fungal infection in elderly patients with malignant tumor.
【Key words】 malignant tumor; hospital fungal infection; risk factor
随着肿瘤综合性治疗的进展和支持治疗的加强，部分肿瘤患者的生存期明显延长。然而，肿瘤患者院内感染发生率增高，特别是老年恶性肿瘤患者合并医院内真菌感染近年有增加的趋势，成为其常见并发症及主要死亡原因之一[12]。真菌感染很少是原发的，宿主体质和各种外在因素均不同程度地参与感染发生。在老年恶性肿瘤患者常因机体抵抗力降低，体内菌群失调或机体免疫功能被抑制而诱发真菌感染。本研究回顾性分析老年恶性肿瘤患者的一般临床资料及相关指标，以期探讨老年恶性肿瘤患者医院内真菌感染的特点及易患危险因素。
1 对象与方法
1.1 资料来源 收集2006年来本院所有老年恶性肿瘤患者住院病历。根据有无真菌感染分为真菌感染组和无真菌感染组。入选病例共219例，男125例，女94例，年龄58～84岁，平均(72.39±9.27)岁。采用统一的调查表核对病历,真菌感染参照国内诊断标准[34]。医院内真菌感染的诊断标准: 上一页 [1] [2] [3] [4] [5] 下一页
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