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老年严重脓毒血症患者和急性心衰患者血浆BNP水平的比较 |
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atients with AHF and 64.15±46.08pg/ml in healthy subjects. BNP level was much higher in patients with sepsis or with AHF than that in healthy old people（P＜0.001）, but there was no difference between the patients with sepsis and AHF (P＞0.05). (2)Despite clear hemodynamic difference between the patients with sepsis and AHF, there was no statistically different between the two groups in BNP level. (3)Plasma BNP level was not correlated with PAOP and CI in patients with severe sepsis(r=0.164 and 0.004, P＞0.05). Conclusions In elderly patients with severe sepsis or septic shock and with HF, BNP level was highly elevated, despite significant hemodynamic difference was found in AHF and sepsis or septic shock patients. The elevations of BNP level was linked to inflammation itself, sepsis_associated myocardial dysfunction and other factors such as age. BNP could not replace hemodynamic index.
［Key words］ Brain natriuretic peptide; Sepsis; Sepsis shock; Heart failure; Elderly
严重脓毒血症（severe sepsis）和感染性休克(septic shock) 及由此引发的多器官功能障碍综合征(MODS) 是重症监护病房(ICU)患者的主要死亡原因。严重脓毒血症和感染性休克时常合并心脏功能抑制［1］。近年来有学者提出将脑利钠肽(Brain natriuretic peptide，BNP)作为严重脓毒血症和感染性休克时的心肌损伤和预后预测生化标志物［2，3］。
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