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空腹血糖受损冠心病患者冠脉病变特点与 血高敏C反应蛋白的关系 |
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sp;blood pressure, blood_lipid, serum creatinine, hs_CRP， CHD risk factors (sex, hypertension, hyper_cholesteremia, smoking) and coronary angiography results were recorded and the coronary narrow degree integral was calculated. Results Plasma hs_CRP level and coronary narrow degree integrals were higher in IFG group than those in control group（P＜0.01）. Correlation analysis showed that the fasting blood glucose and plasma hs_CRP level in CDH with IFG were positively correlated with the coronary narrow degree integrals (r=0.2685 and 0.5232. respectively P＜0.05). Conclusions The coronary multivessel lesions， severe lesions and diffuse stenosis were more frequent in CHD with IFG. CHD with IFG had abnormal inflammation reaction. Plasma hs_CRP level reflected the severity of coronary artery lesions.
［Key words］ Coronary heart disease；Impaired fasting blood glucose；Oral glucose tolerance test；High sensitive C_reactive protein；Coronary narrow degree integral；Coronary angiography
据1999年WHO定义［1］空腹血糖受损(IFG)是指空腹血浆葡萄糖(FPG)6.1～6.9mmol/L，75g口服葡萄糖耐量试验(OGTT)2h血糖(PG2h)＜7.8mmol/L。IFG人群虽仅有空腹血糖升高，但与糖耐量低减(IGT)人群一样具有向糖尿病发展的高危倾向，存在发生大血管并发症的危险［2］。本文对冠心病合并IFG患者冠脉病变特点及与血高敏C反应蛋白(hs_CRP)的相关性进行分析，探讨其在冠心病的发生、发展中的关系及意义。
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