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白血病患者炎症因子 VEGF表达与易栓状态关系的研究 |
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【摘要】 目的 了解白血病患者表达炎症因子IL6、IL8、IL10与VEGF的水平与意义。方法 以ELISA方法观察30例正常人和47例白血病患者血清IL6、IL8、IL10、VEGF水平。结果 初治患者血清IL6、IL8、IL10、VEGF水平均明显高于对照组(P＜0.05)。部分缓解组IL6、IL8、IL10、VEGF较治疗前明显降低(P＜0.05)，但仍高于对照组。完全缓解时渐趋正常。结论 炎症因子与VEGF在白血病不同病期变化，除了肿瘤性病因所致，也与肿瘤性血管内皮损伤有关，导致肿瘤性易栓状态。这些因子可作为观察白血病患者合并高凝状态观察指标。
【关键词】 白血病； 炎症因子
The Relation Between Thrombophilia and Inflammatory Factor, VEGF in Leukemia
SHI Jianxia , GU Jian , HE Bin, SUN Mei , MA Li
(The Subei People’s Hospital of Jiangsu, Yangzhou 225001, China)
Abstract： Objective The expression and significance of IL6, IL8, IL10, VEGF in acute and chromic leukemia. Methods The serum leveles of IL6, IL8, IL10, VEGF in 47 patients with acute and chromic leukemia and 30 normal people were measured by ELISA method. Results Before therapy patients with acute and chromic leukemia had a higher levels of IL6, IL8, IL10, VEGF compared to other groups(P＜0.05). After therapy of acute and chromic leukemia who were partial remission IL6, IL8, IL10, VEGF all decreased compared to before therapy(P＜0.05), but they still had higher levels compared to normal control group. There was no evident&[1] [2] [3] [4] [5] 下一页
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