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骨质疏松的遗传因素

ogen receptor genotypes with bone mineral density and estrogen responsiveness to hormone replacement therapy in Korean postmenopausal women. J Clin Endocrinol Metab, 1997,82:991-955.

  10,Gennari L, Becherini L, Masi L, et al. Vitamin D and estrogen receptor allelic variants in Italian postmenopausal women: Evidence of multiple gene contribution to bone mineral density. J Clin Endocrinol Metab, 1998,83:939-944.

  11,Willing M, Sowers M, Aron D, et al. Bone mineral density and its change in white women: estrogen and vitamin D receptor genotypes and their interaction. J Bone Miner Res, 1998,13:695-705.

  12,Korkko J, Ala-kokko L, Paepe AD, et al. Analysis of the COLIA1 and COLIA2 genes by PCR amplification and scanning by conformation-sensitive gel electrophoresis identifies only COLIA1 mutations in 15 patients with osteogenesis imperfecta type I: Identification of common sequences of null-allele mutations. Am J Hum Genet, 1998,62:98-110.

  13,Uitterlinden AG, Burger H, Huang QJ, et al. Relation of alleles of the collagen type I α1 gene to bone density and the risk of osteoporotic fractures in postmenopausal women. N Engl J Med, 1998,338:1016-1021.

  14,Keen RW, Woodford-Richens KL, Grant SFA, et al. Association of polymorphism at the type I collagen (COLIA1) locus with reduced bone mineral density, increased fracture risk, and increased collagen turnover. Arthritis Rheum, 1999,42:285-290.

  15,Landahl BL, Ralston SH, Grant SF, et al. An Sp1 binding site polymorphism in the COLIA1 gene predicts osteoporotic fractures in both men and women. J Bone Miner Res, 1998,13:1384-1389.

  16,Uangdahl BL, Knudsen JY, Jensen HK, et al. A sequences variation: 713-8delC in the TGF-β1 gene has higher prevalence in osteoporotic women than in normal women and is associated with very low bone mass in osteoporotic women and increased bone turnover in both osteoporotic and normal women. Bone, 1997,21:289-294.

  17,Yamada Y, Miyauchi A, Goto

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