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瘦素与慢性肾功能衰竭

不良、胰岛素抵抗、高血压、免疫功能受限、贫血等病理生理紊乱有关,但机制还不完全清楚,有待进一步深入研究。

  参考文献

  1 Young GA,Woodrow G,Kendall S et al.Increased plasma leptin/fat ratio in patients with chronic renal failure:a cause of malnutrition?Nephrol Dial Transplant,1997,12:2318

  2 Zhang Y,Poenca R,Maffei M et al.Positional cloning of the mouse obese gene and its human homologue.Nature,1994,372:425

  3 Halaas JL,Gajiwala KS,Maffei M et al.Weight-reducing effects of the plasma protein encoded by the obese gene.Science,1995,269:543

  4 Cohen B,Novik D,Rubinstein M et al.Modulation of insulin activites by leptin.Science,1996,274:1

  5 Merabet E,Dagogo-Jack S,Coyne DW et al.Increased plasma leptin concentration in end-stage renal disease.J Clin Endocrinal Metab,1997,82:847

  6 Masuzaki H,Ogava V,Isse N et al.Human obese gene expression.Adipocyte-specific expression and regional differences in the adipose tissue.Diabetes,1995,44(7):855

  7 Considine RV,Sinha MK,Heiman ML et al.Serum immunoreactive concentrations in normal weight and obese humans.N Engl J Med,1996,334:292

  8 Saad MF,Rial-Gabriel MG,Khan A et al.Diurnal and ultradian rhythmicity of plasma leptin:effects of gender and adiposity.J Clin Endocrinol Metab,1998,83:453

  9 Narkiewicz K,Szczech R,Winnicki M et al.Heritability of plasma leptin levels:a twin study.J Hypertension,1999,17:27

  10 Chen H,Charlat 0,Tartaglia LA et al.Evidence that the diabetes gene encodes the leptin receptor:identification of a mutation in the leptin receptor gene in db/db mice.Cell,1996,84:491

  11 Kolaczynski JW,Nyce MR,Considine RV

et al.Acute and chronic effect of insulin on leptin production in humans:studies in vivo and in vitro.Diabetes,1996,45:699

  12 Caro JF,Sinha MK,Kolaczynski JW et al.Leptin:the tale of an obesity gene.Diabetes,1996,45:1455

  13 Jackson EK,Li P.Human leptin may function as a diuretic/natriuretic hormone.Hypertension,1996,28:517

  14 Shek EW,Brands MW

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