Studies of Eph-subfamily Receptor Tyrosine kinases.ZHANG xiao-Guang.YAO Li-Bo, SU Cheng-Zhi
( Department of Biochemistry and Molecular biology,the Fourth Military Medical University,Xi an 710032,China)
Abstract Receptor tyrosine kinases(RTSs) are involved in many different processes including cellular growth,differentiation,embryonic development,oncogenesis and intracellular signalling pathways,thus possessing improtant physiological functions,There are now more than 50 distinct RTK genes that have been published and divided into 14 sub-families, the largest one knnwn is the Eph sub-family which is comprised of at least fifteen members Some of the Eph family members are predominantly expressed in the developing brain,the others are express
ed in a broader range of tisues .Recently the findings of the excellular ligands of this family should facilitate further studies of its function .The isolation,pattern of expression and the ligands of Eph-like receptors are summarised. Key words receptor tyrosine kinase( RTK),Eph-subfamily,ligand
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