tion in renal tubular epithelial cells pre-incubated with lck inhibitor PP1,while the inhibitory effects were mild in renal tubular epithelial cells stimulated with IL-2 or LPS.Conclusion IL-12,IL-2 and LPS may promote lck gene express in renal tubular epithelial cells and only IL-12 can induce p38 phosphorylation through lck uniquely,and they can play biologic role in renal tubular epithelial cells via lck/ p38 signaling pathways. Keywords：Renal tubule;Epithelial cells;Signal transduction;Lymphocyte-specific protein-tyrosine kinase;p38
基金项目：卫生部基金资助项目(94-1-105)
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