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组织纤维化中细胞因子与Decorin的作用

mall proteoglycans,collagen and transforming growth factor-β1 in developing bleomycin-induced pulmonary fibrosis in rats,J clin Invest,1993;92:632-637

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  [18]Kuroda K,Shinkai H.Gene expression of types I and Ⅲ collagen,decorin,matrix metalloproteinases and tissue inhibitors of metalloproteinases in skin fibroblasts from patients with systemic sclerosis.Arch Dermatol Res,1997;289:567-572

  [19]Yamaguchi Y,Mann DM,Ruoslahti E,Negative regulation of tr


ansforming growth factor-β by the proteoglycan decorin.Nature,1990;346

:281-284

  [20]Asakura S,Kato H,Fujino S,Konishi T,Tezuka N,Mori A.Role of transforming growth factor-β1 and decorin in development of central fibrosis in pulmonary adenocarcinoma.Hum Pathol,1999;30:195-198

  [21]Wegrowski Y,Paltot V,Gillery P,Kalis B,Randoux A,Maquart FX.Stimulation of sulphated glycosaminoglycan and decorin production in adult dermal fibroblasts by recombinant human interleukin-4.Biochem J,1995;307:673-678

  [22]Isaka Y, Brees DK, Ikegaya K, Kaneda Y.Imai E, Noble NA. Bonder WA.Gene therapy by skeletal muscle expression of decorin prvents fibrotic disease in rat kidney.Nat Med,1996;2:418-423

  [23]Giri SN,Hyde DM,Braun RK,Gaarde W,Harper JR,Pierschbacher mD,Antifibrotic effect of decorin in a bleomycin hamster model of luing fibrosis.Biochem Pharmacol,1997;54:1205-1216

  [24]Santra M, Skorski T,Calabretta B,Lattime EC,Iozzo RV.De novo decorin gene expression suppresses the malignant phenotype in human colon cancer cells.Proc Natl Acad Sci USA,1995;92:7016-7020

  [25]Patel S,Santra M,McQuillan DJ,Iozzo RV,Thomas AP.Decorin activates the epidermal growth faactor receptor an elevates cytosolic Ca2+in A431 carcinoma cells.J Biol Chem,1998;273:3121-3124

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