中药胃炎消治疗大鼠慢性萎缩性胃炎的病理研究

　　摘　要：　　目的 观察中药胃炎消对实验性大鼠慢性萎缩性胃炎的治疗作用。方法 采用主动免疫、去氧胆酸钠、热水灌胃综合法连续造模90d，复制慢性萎缩性胃炎(CAG)大鼠模型，胃炎消按照临床用量的5倍、10倍(12．3g/kg，24. 6g/kg)灌胃绐药，连续治疗60d进行胃液分析及病理组织学观察．光镜下观察胃粘膜的炎症程度并分级计分，用测微尺测量胃粘膜厚度、粘膜肌层厚度、胃体部胃小凹深度及胃腺长度并取其比值．结果 非治疗模型组大鼠胃窦部、窦体交界、前胃与腺胃交界处的炎症计分分别为1．98±0．16．1.53±0．51，L81±0.40,明显高于正常对照：1．54±0.49(P＜0．01)．1．20±0.14(P＜0．05)．1.40±0．54(P＜0．05)；胃窦部粘膜厚度(μm)为278±32,明显少于正常对照349±33(P

Pathologic studies of Chinese drug Weiyanxiao on experimental chronic atrophic gastritis in rats

Ru Jun Wang ,Qun Du ,Ting Yin Shao , Ting Ji Zhong ,Yan Li Wu ,Jian Hua Wang

　　(Correspondence to: Ru Jun Wang, Piwei Institute, Guangzhou Univrsity of Traditional Chinese Medinine,Guangzhou 510405, Guangdong Province,China)

　　Abstract：ALM To study the effects of Weiyanxiao (WYX) on experimental chronic atrophic gastritis(CAG) in rats.METHODS CAG model in rats was made using complex methods of active immunization combined with oral administration of sodium deoxycholate and hot water for 90 d. Followed by the treatment with administration of WYX orally in the dosages of 12.3 g/kg and 24.6 g/kg (5 and 10 times according to the clinic dosages) for 60 d.Then the acidity of gastric juice was measured using acid-base balance. The histopathological changes including the depth of mucosa, muscular layers, gastric pit and length of gastric glands were measured with microxneter under optical microscope. The degrees of inflammation in gastric mucosa were evaluated with score according to the numhers of inflammatory cells.RESULTS in untreated grcup, the inflammatory score of gastric antrum, antrum-body junction and proventriculus-body junction were 1.98 μm ± O. 16μm, 1.53μm±0.51μm end 1.81μm ±0.40μm respectively, which were significantly higher than that of normal group (1.54μm±0.49μm, P＜0.01, 1.20μm±0.14μm, P＜0.05, 1.40μm±0.54μm, P＜0.05); mucosa depth in antrum was 278μm±32μm, which is significantly rower than that in normalgrcup (349μm±33μm. P＜0.05); the depth of mucoas muscular layer

[1] [2] [3] [4] 下一页