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口服耐受及鼻粘膜耐受治疗神经系统自身免疫病

on of diabetes in the NOD mouse by oral administration of porcine insulin. Proc Natl Acad Sci USA,1991, 88:10252-10256

  13 Lider O, Santos LMB, Lee CSY, et al. Suppression of experimental allergic encephalomyellitis by oral administration of myelin basic protein. II. suppression of disease and in vitro immune responses is mediated by antigen-specific CD8+ T lymphocytes. J Immunol, 1989, 142:748-752

  14 Miller A, Lider O, Weiner HL. Antigen-driven bystander suppression after oral administration of antigens. J Exp Med, 1991, 174:791-798

  15 Sun JB, Holmgren, Czerkinsky C. Cholera toxin B subunit:an efficient transmucosal carrierdelivery system for induction of peripheral immunological tolerance. Proc Natl Acad Sci USA, 1994, 91:10795-10799

  16 Sun JB, Rask C, Olsson T, et al. Treatment of experimental autoimmune encephalomyelitis by feeding myelin basic protein conjugated to cholera toxin B subuint. Proc Natl Acad Sci USA, 1996, 93:7196-7201

  17 Ma CG, Zhang GX, Xiao BG, et al. Suppression of experimental autoimmune myasthenia gravis by nasal administration of acaetylcholine receptor. J neuroimmunol, 1995, 58:51-60

  18 Ma CG, Zhang GX, Xiao BG, et al. Cellular mRNA expression of IFN-γ IL-4 and TGF-β in rat nasally tolerized against experimental autoimmune myasthenia gravis. Clin Exp Immunol, 1996, 104:509-517

  19 Weiner HL, Mackin GA, Matsui M, et al. Double-blind pilot trial of tolerization with myelin antigens in multiple sclerosis. Science. 1993,259:1321-1324

  20 Weiner HL, Friedman A, Miller A, et al. Oral tolerance:Immunologic mechanisms and treatment of murine and human organ-specific autoimmune diseases by oral administration of autoantigens. Ann Rev Immunol, 1994, 12:809-837

  21 Weiner HL. Oral tolerance: immune mechanisms and treatment of autoimmune diseases. Immunology Today, 1997, 18:335-343

  22 Trentham DE, Dynesium-Trentham A, Orav EJ, et al. Effects of oral administratiion of type II c

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