显示,以急性左心衰竭为主要表现的AMI有以下特征:胸痛症状隐匿,有长期劳力型心绞痛病史,多有OMI及梗死前心绞痛;多并存高血压、糖尿病和高脂血症;多有吸烟史。因此,如能提高警惕,结合上述临床特点,密切观察心电图和血清酶的动态变化,仍可尽快作出AMI诊断。 二、AMI并发急性左心衰竭的发生机制
AMI并发急性左心衰竭较多见于前壁梗死〔1〕,因为前壁梗死对心功能影响较大,本组亦如此。本组8例患者LVEF<40%,显示左室收缩功能严重受损是这部分患者发生急性左心衰竭的主要机制。LVEF≥40%的14例中,7例左室舒张末期内径>55 mm,有收缩功能低下,7例左室舒张末期内径≤55 mm,被视为左室收缩功能未受明显影响。因此,Dougherty等〔2〕认为左室舒
张功能严重受损是这部分患者心力衰竭的主要原因。本组患者舒张功能受损是由于较多患者有OMI及并存高血压和糖尿病,使左室舒张功能受到原发性损害,同时急性心肌缺血又使左室舒张功能受到顿挫性损害。与文献报道一致〔3-5〕。 三、AMI并发急性左心衰竭患者的预后
AMI并发急性左心衰竭的患者1年内病死率为28%~57%〔1,6〕,且死亡多发生于半年内〔7〕。本组随访结果与上述报道一致。降低病死率的关键是及时诊断和治疗AMI,并在急性左心衰竭的治疗中有针对性地改善心脏收缩功能及舒张功能状况。
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