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寻常型银屑病患者白细胞介素1受体拮抗剂基因多态性的研究 |
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1ra产生水平有关,A2携带率增加,导致IL-1ra产生水平下降,引起IL-1r表达,继而引起IL-1浓度升高,这可能是引起银屑病皮肤炎症性病损的重要原因。另外也提示,A2是一种与皮肤炎症有关的非HLA的又一新的免疫学基因,是否是易患寻常型银屑病的标志尚值得深入研究。 参考文献
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