氧疗对高原系统性红斑狼疮QT离散度的影响

作者：李蔚林　李东辉　田忠新　孙淑萍　黄维英

摘要：目的　探讨氧疗对改善高原系统性红斑狼疮（PSLE）QT离散度（QTd）增大的作用。方法　PSLE实验组28例，在激素、免疫抑制剂、中药等治疗基础上每日吸氧2次，每次60 min,流量5 L/min；对照组30例，不吸氧，余方法同实验组。对比观测治疗前与治疗0.5，1，2，3月的QTd变化，判定其统计学意义。结果　(1)配合氧疗的实验组治疗0.5月时QTd减小极显著（P＜0.01），以后各期减幅较小，仅治疗0.5月与3月间差异显著。未吸氧的对照组治疗0.5，1月时变化不显著(P＞0.05），治疗2，3月与治疗前、治疗0.5月与3月比较差异极显著（P＜0.01），治疗2月与3月比较仍有显著差异（P＜0.05）。(2)实验组病情稳定与非稳定患者治疗0.5月时QTd减幅均较大，其后前者继续减小直至正常，后者始终波动在较高水平。结论　氧疗改善PSLE增大的QTd参数值早期作用较明显，故其适用于早期治疗。
关键词：高原； 心电描记术； 心肌缺氧；系统性红斑狼疮
中图分类号：R459.6　　文献标识码：A
文章编号：1008-9993(2000)02-0006-03

Influence of Oxygen Therapy on QT Dispersion in Patients with Plateau Systemic Lupus Erythematosus

LI Wei-lin,LI Dong-hui,TIAN Zhong-xin,SUN Shu-Ping,HUANG Wei-ying
(Department of Dermatology,No.4 Hospital of PLA,Xining,810014,China)

Abstract：Objectve　The study aims to determine whether oxygen therapy improves effectively QT dispersion(QTd) in patients with plateau systemic lupus erythematosus(PSLE).Methods　 28 cases of experimental group were treated by oxygen therapy(twice a day,each for 60 min,5 L/min),at the same time they were treated by medicine. 30 cases of control group were treated only by the same medicine.The changes of QTd before treatment and 0.5,1,2,3 month after treatment were determined.Results　(1) The QTd decreased very much after 0.5 month(P＜0.01),while it reduced few at other time points and the difference only between 0.5 and 3 month aftr treatment was found in experimental group(P＜0.01).No difference was observed between before treatment and 0.5,1 month after treatment(P>0.05),while the remarkable difference between before treatment and 2,3 month after treatment (P＜0.01),between 0.5 and 3 month after treatment(P＜0.01) and between 2 and 3 month after treatment(P<0.05) were found in experimental group;(2)The QTd of 0.5 month after treatment reduced very much in experimental group including stable patients and unstable patients.Gradually,stable patients condition became

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