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川芎嗪对慢性肺原性心脏病急性加重期患者血小板活化功能的影响 |
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徐德斌 刘树芬 张劭夫 孙晓明
【摘要】 目的 探讨肺心病患者血小板活化功能的变化及川芎嗪对其影响。方法 46例慢性肺心病急性加重期患者随机分为2组,A组24例进行常规治疗;B组22例在常规治疗基础上给予川芎嗪注射液120 mg/d静滴,疗程均为15日。治疗前后应用流式细胞仪测定外周血血小板CD62P及血小板膜Fg含量,并以20例健康人作对照。结果 肺心病患者血小板CD62P及血小板膜Fg含量均显著高于健康人(P＜0.01),治疗后显著低于治疗前(P＜0.01),治疗后B组显著低于A组(P＜0.01)。结论 肺心病患者血小板活化程度增加在肺心病发病中起一定作用,川芎嗪可有效降低肺心病患者血小板活化功能。
【关键词】 肺心病 血小板 P-选择素 纤维蛋白原 川芎嗪
Effects of ligustrazine on platelet activation in patients with chronic cor pulmonale
Xu Debin,Liu Shufen,Zhang Shaofu,et al.
General Hospital,Jinan Command of PLA,Jinan 250031
【Abstract】 Objective To study the change of and the effects Ligustrazine on acivation of platelet in patients with co pulmonale.Methods 46 cases of cor pulmonale in exac-erbation were randomly divided into 2 groups,group A(n=24)was treated by routine therapy;group B(n=22)was treated by routine therapy + ligustrazine,120mg/d,i.v. The therapeutic courses in both groups were 15 days Before and after treatment,positive platelet percents of p-selectin(CD62Pand bound fibrinogen(Fg) in peripheral blood were examined by flow cytometric immunology respectively.20 healthy volunteer served as control group.Results CD62 Pand Fg in patients with cor pulmonale before and after treatment were higher significantly than those in contral group(P＜0.01),CD62Pand Fg in patients with cor pulmonale after treatment decreased markedly as compared to those before treatment(P＜0.01),CD62P and Fg in group B after treatment were significantly lower than those in group A after treatment(P＜0.01).Conclusion These results suggest that activated platelet may be involved in pathogenesis of cor pulmonale and ligustrazine can decrease activated platelet activation effectively in patients with cor pulmonale.
【Key words】 Pulmonary healt disease Platelet P-selectin Fibrinogen Ligustrazine
研究表明慢性阻塞性肺病(COPD)患者肺动脉血栓形成率为20%～50%,合并肺动脉高压、肺心病者血栓形成率更高［1］。而研究其中血小板功能变化及药物对其影响的报道甚少。我们检测了46例慢性肺心病急性加重期患者外周血血小板活化特异标志物血小板[1] [2] 下一页
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