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奥宁治疗尿路刺激症的疗效观察 |
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病人肝、肾功能及血象无影响[3]。本文观察组1例发生尿潴留,8例出现口干;对照组1例出现皮肤瘙痒,5例出现口干,均无严重不良反应发生。通过本组观察,证实国产奥宁完全可与进口尿多灵相媲美,且国产制剂有价兼的优点。 作者单位:王琼瑶(湖南省株洲湘江药业股份有限公司 株洲 412011) 杨金瑞(湖南医科大学第二附属医院 长沙 410011)
参考文献 1 Robert ML,Alan JW.Direct measurement of the anticholinergic activity of a series of pharmacological compounds on the canine and rabbit urinary bladder.J Urol,1982,128:396 2 Tonini M,Bizzi CA,Perucca E,et al.Depressant action of oxybutynin on the contractility of intestinal and urinary tract smooth muscle.J Pharm Pharmacol,1987,39(2):103 3 Lish PM,Labudde JA,Peters EL,et al.Oxybutynin-amusculotropic antispasmodic drug with moderate anticholinergic action.Arch Int Pharmacodyn,1965,156:467 4 Ananias CD,Jack L.Oxybutynin:a new drug with analgesic and anticholinergic properties.J Urol,1972,108:307 5 Algate DR,Beard DJ.The physical dependence liabilities of oxybutynin and morphine in rats.Arzeim Forsch,1985,35:1577
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