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急性脊髓损伤后血清中ALT和AST活性变化的临床初步观察 |
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郭金兰 周国昌
摘要：目的：探讨血清中谷丙转氨酶(ALT)和谷草转氨酶(AST)的活性与急性脊柱脊髓损伤的关系，并评价ALT和AST活性的变化与脊髓损伤严重程度的关系。方法：测定136例急性脊柱脊髓损伤患者在急性期及恢复期血清中ALT和AST的水平，以及30例急性脊柱骨折患者血清中ALT和AST的浓度，分别进行统计学处理分析。结果：急性脊柱脊髓损伤患者血清中ALT和AST活性显著高于其恢复期及单纯脊柱骨折患者，并且在急性期脊髓完全损伤患者血清中ALT和AST活性明显高于脊髓不完全损伤患者。结论：ALT和AST水平改变与脊髓损伤及其严重程度可能有一定关系。
关键词：脊髓损伤；谷丙转氨酶；谷草转氨酶
中图分类号：R49 文献标识码：A
文章编号：1006-9771(2000)03-0102-03
The determination of ALT and AST of patients with acute spinal cord injury
GUO Jinlan,ZHOU Guochang
Abstract:Objective:In order to evaluate the relationship between the activity of ALT and AST and the degree of spinal cord injury,we analyzed the activity of ALT and AST in serum of the patients with acute spinal cord injury(ASCI),the patients with fracture of spine and the ASCI patients at the recovery stage.Methods:We investigated the ALT and AST activity in serum of 136 SCI patients in acute and recovery stages respectively by auto Olympus 600 biochemistry analysis instrument.Results:The activity of ALT and AST of ASCI patients is much higher than that at recovery phase,and it is also higher than that of patients with spinal column fracture,while activity of patients with complete spinal cord injury is higher than that of patients suffered from incomplete spinal cord injury.Conclusion:The activity of AST and ALT in serum may be related to spinal cord injury and its degree.
Key words:spinal cord injury;ALT;AST
ALT和AST的活性检测在生化检测中主要作为肝脏功能及心脏病变的特异性指标。当突发心肌梗死或急性肝病导致细胞膜通透性增加或造成细胞破坏时，ALT或AST可分别大量移入血液而使血清中活性明显增高。通过临床观察发现，AST及ALT的活性在急性脊髓损伤患者中也可发生改变。本文就急性脊髓损伤时ALT和AST活性的变化及其发生机制进行探讨。
1 材料与方法
136例急性脊柱脊髓损伤患者及30例急性脊柱骨折患者均为北京博爱医院住院患者，年龄在17～75岁，平均年龄为45岁，男、女比例3∶1。患者伤前皆为无肝病史及心脏病史的健康人。其中急性脊髓完全损伤患者为70例，不完全脊髓损伤患者为66例。患者受伤后6周以内为急性期，受伤6周以后为恢复期。
急性脊柱脊髓损伤患者和急性脊柱骨折患者于急性期和恢复期分别采取静脉血，标本用Olympus 600(日)全自动生化分析仪行ALT和AST测定。用两组样本t检验对数据进行统计学分析。
2 结果
136例脊髓损伤患者及30例脊柱骨折患者血清中AST和ALT在急性期和恢复期的数据统计无性别、年龄差异，统计结果[1] [2] 下一页
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