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运动对糖尿病大鼠骨骼肌细胞胰岛素受体及葡萄糖运载体的影响 |
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吴 毅1 李益明2 冯光斌1 胡永善1 占 飞1 朱尚权3 张新堂3
摘要 目的：研究运动对链脲佐菌素所致的糖尿病大鼠骨骼肌细胞葡萄糖运载体4(GLUT4)基因表达及胰岛素受体结合的影响。方法：实验大鼠分成3组：糖尿病运动组、糖尿病非运动组和正常对照组。糖尿病运动组大鼠进行6周游泳耐力训练。结果：糖尿病运动组大鼠与糖尿病非运动组大鼠相比，血糖水平降低、体重增加，骨骼肌细胞膜胰岛素受体结合力有所降低，而细胞内 GLUT4 mRNA 含量增加56％(P＜0.01)。结论：运动训练主要减少了糖尿病大鼠骨骼肌细胞胰岛素受体后的抵抗，增加了骨骼肌细胞转运和利用葡萄糖的能力，从而改善了糖尿病糖代谢紊乱。
关键词 运动；糖尿病；胰岛素受体；葡萄糖运载体
Effects of exercise on insulin receptor and glucose transporter of skeletal muscle cell in diabetic rats/WU Yi, LI Yiming , FENG Guangbin, et al//Chinese Journal of Rehabilitation Medicine,1998,13(2):50～53
Abstract Objective:To investigate the effect of the exercise on glucose transporter4 (GLUT4) gene expression and insulin binding in streptozotocin-induced diabetic rat skeletal muscle.Methods: Three experiment groups of rats were investigated: an exercise diabetic group, an unexercised diabetic group and a normal control group. The diabetic exercise rats were swim-trained for 6 weeks.Results:The exercise diabetic group after swimming training had a lower blood glucose level and a higher body weight increasing than that of the untrained diabetic group. In exercise diabetic group, the insulin binding of muscle cell membranes decreased significantly and GLUT4 mRNA increased 56% in muscle cells, compared with the unexercise diabetic group(P＜0.01). Conclusion:Exercise training may improve the impaired GLUT4 expression in diabetic rats. It might improve the insulin resistance at post-receptor sites, enhance the ability of transportation and utilization of glucose in muscle cell and decrease hyperglycemia in diabetes mellitus.
Author′s address Dept. of Rehabilitation Medicine, Huashan Hospital,Shanghai Medical University, Shanghai, 200040
Key words Exercise;Diabetes mellitus;Insulin receptor;Glucose transporter
外周组织对胰岛素的抵抗是非胰岛素依赖型糖尿病(non-insulin dependent diabetes mellitus,NIDDM)主要病理特征。胰岛素抵抗可发生在胰岛素受体水平或胰岛素受体后水平〔1〕。目前已知外周组织细胞膜上葡萄糖运载体4(glucose transporter4, GLUT4)[1] [2] 下一页
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