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不同程度肝硬变患者甲状腺素 性激素及促性腺激素的变化 |
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邹红 刘玉兰 张永利 孙思政
摘 要：检测77例男性肝硬变患者(肝硬变组)和34例健康男性(对照组)血清甲状腺激素和性激素水平，并采用Child-Pugh分级法将上述病例分为A级(24例)、B级(32例)和C级(21例)。结果显示，肝硬变组T3、T4明显低于对照组;rT3明显高于对照组，有显著性差异。肝硬变组Child-Pugh记分与rT3浓度呈正相关(r=0.48,P＜0.01)，与T3、T4浓度无明确相关(P＞0.05)。肝硬变组FSH,LH和PRL明显高于对照组;T和E2明显低于对照组。Child-Pugh记分与T水平呈负相关(r=-0.58，P＜0.01)，与PRL浓度呈正相关(r=0.35,P＜0.01)，与FSH，LH和E2无明确相关。提示肝功能受损可能是导致肝硬变患者甲状腺激素和性激素异常的重要原因，rT3、T和PRL对肝硬变患者的预后有一定的指示意义。
关键词：肝硬变 甲状腺激素 性激素 促性腺激素
The change of thyroid hormones, sex hormones and gonadotrophin in different degrees of the cirrhosis patients
Zou Hong
(The Digestive Department of People s Hospital, Beijing Medical University, Beijing 100044)
Zhang Yongli
(The Digestive Department of People s Hospital, Beijing Medical University, Beijing 100044)
Sun Sizheng
(The Digestive Department of People s Hospital, Beijing Medical University, Beijing 100044)
Abstract：The serum concentrations of thyroid hormones, sex hormones and gonadotrophin were measured in 77 male cirrhotic patients (cirrhosis group) and 34 health men (control group). The severity of cirrhosis was graded according to Child-Pugh s classification. There were 24 grade A, 32 grade B and 21 grade C patients. Serum triodothyroxine (T3) and thyroxine (T4) were singificantlv lower in the cirrhosis group, but rT3 was significantly higher than the control group. There was a positive correlation between serum rT3 levels and Pugh s score (r=0.48,P＜0.01). Serum follicle-stimulating hormone (FSH), luteinizing hormone (LH)and prolatin (PRL) were significantly higher in the cirrhosis group than in the control group, serum testosterone (T) and estradiol (E2) were significantly lower in the cirrhosis group than in the control group. There was negative correlation between serum T levels and Pugh s score (r=-0.58,P＜0.01),but a positive correlation between Pugh s score and PRL level (r=0.35,P＜0.01),and no marked correlation among FSH, LH and E2. The res[1] [2] [3] 下一页
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