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小儿呼吸道合胞病毒感染的病原学与临床研究 |
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车莉 卢竞 刘成贵 苏英姿 姜晶 陈慧中 张梓荆
摘 要：目的 探讨我院急性呼吸道感染合胞病毒的病原学及临床研究。方法 对急性下呼吸道病毒感染的门诊及住院患儿在不同年份RSV感染的情况进行了临床监测和比较。结果 冬春季急性呼吸道感染患儿RSV检测阳性率平均在27.8%。结论 RSV是婴幼儿呼吸道感染病原中主要的病毒，其发病年龄高峰在1岁以内(70%)，其中2～6个月发病率最高(44.8%)，并且毛细支气管炎患儿RSV感染率明显高于支气管炎和支气管肺炎。
关键词：呼吸道合胞病毒 感染
The aetiological and clinical investigation of Respiratory
syncitial virus infection during the spring and winter in Beijing
Che Li
(Capital Institute of Pediatrics, Beijing 100020)
Lu Jing
(Capital Institute of Pediatrics, Beijing 100020)
Liu Chenggui
(Capital Institute of Pediatrics, Beijing 100020)
Abstract：In the worldwide, respiratory syncitial virus(RSV) infection is the most common cause in the lower respiratory tract infection in infants. In our counrty, the peak period of RSV infection is during spring and winter in north area, epidemiologically. The conditions of the RSV infection in patients suffered form acute respiratory tract infection in our hospital gained from 1993～1998 were monitored and compared, clinically. The results indicated that the average rate of RSV(+) during the five years is 27.84%. The highest rate of RSV(+) was in 1996(34.29%), and the lowest rate of RSV(+) was in 1995(21.15%).RSV is the major pathogen in respiratory tract infection in infants. The peak age of the infection was within 1 year old(70%), and the highest incidence developed during 2～6 months old was 44.8%. The rats of RSV infection in patients with bronchiolitis was higher than that in patients with bronchitis and tracheitis.
Key word：Respiratory syncitial virus (RSV) Infection▲
呼吸道合胞病毒(RSV)感染，在全球范围内是小儿下呼吸道感染的主要病原之一［2］，在我国北方地区流行高峰主要在冬春季。我们连续5年在冬春季节，对我院急性呼吸道感染的门诊及住院患儿，在不同年份RSV感染的情况进行了临床监测和比较。
对象和方法
一、对象
观察对象为1993年11月～1998年3月冬春季节发病1周以内，在我院门诊就诊和住院的急性下呼吸道感染患儿共449例，年龄32天～10岁。共收集449例患儿的鼻咽分泌物，鼻咽拭子和血清标本送我所病毒研究室检测。
二、实验室检测
1.血清学检测：采集患儿急性期和恢复期双份血清标本，应用间接免疫荧光方法，测定RSV抗体，恢复期较[1] [2] [3] 下一页
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