[摘要] 目的 探讨更昔洛韦治疗小儿腺病毒肺炎的疗效及安全性。方法 用更昔洛韦治疗52例小儿腺病毒肺炎,并以43例患儿作为对照给予病毒唑治疗。结果 治疗组治愈率达90.2%,总有效率100%;对照组治愈率63.2%,总有效率85.32%,两组治愈率与总有效率比较,差异有非常显著性(P<0.01);治疗组咳嗽、喘息、肺部音以及热退时间均明显短于病毒唑对照组,差异有非常显著性(P<0.01)。治疗组未发现明显毒副作用。结论 更昔洛韦用于治疗小儿腺病毒肺炎疗效显著,优于病毒唑,值得临床推广运用。
[关键词] 更昔洛韦;病毒唑;腺病毒肺炎
Efficacy of ganciclovir therapy for patients with children adenovirus pneumonia
LI Weihua,ZHANG Chonglin.Xuzhou Children’s Hospital,Xuzhou 221006,China
[Abstract] Objective To evaluate the efficacy and safety of ganciclovia therapy for children adenovirus pneumonia.Methods 95 patients with children adenovirus pneumonia were randomly divided into two groups,therapy group with 52 cases and control group with 43 cases,patients in therapy group were administered with ganciclovir,ribavirin in control group.Results In therapy groups,effective rates were 100% and 85.32% respectively,cure rates were 90.2% and 63.2% respectively.There was a significant difference between two groups.No side effect was observed in therapy group.
Conclusion Efficacy of ganciclovir is better than ribavirin.It’s worthy of application.
[Key words] ganciclovir;ribavirin;adenovirus pneumonia
儿童腺病毒(ADV)感染较普遍,除引起上呼吸道感染外,还可导致肺炎,3岁以内呼吸道感染5%可波及到下呼吸道[1],往往发病急,中毒症状重,咳嗽、喘憋明显。为探讨更昔洛韦治疗小儿腺病毒肺炎的有效性及安全性,笔者运用更昔洛韦对52例小儿腺病毒肺炎进行治疗,取得了良好的疗效,现总结如下。
1 资料与方法
1.1 一般资料
将2003年10月~2005年1月我院呼吸内科收治住院的95例小儿腺病毒肺炎患儿随机分为治疗组52例和对照组43例。95例患儿中,男60例,女35例;年龄3个月~2.5岁,治疗组(15.00±6.70)个月,对照组(14.30±5.80)个月;两组患儿均有发热,临床表现:骤然发热(体温>39 ℃),3~4天后出现肺部症状、体征(阵发性咳嗽、干咳或频咳、呼吸困难及发绀;双肺可闻及湿音),中毒症状重(精神萎靡、嗜睡、烦躁、面色苍白等),X线胸片可见双肺纹理增粗或右上肺、两下肺斑片状阴影,或肺部大片融合性病灶,查血清腺病毒抗体阳性,血常规白细胞计数<10×109/L,痰细菌学检测阴性。均符合《诸福棠实用儿科学》腺病毒肺炎诊
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