【摘要】 目的 探讨弥散性血管内凝血（DIC）患儿凝血障碍的检测及临床意义。方法 用免疫法、发色底物法和凝固法分别测定39例DIC患儿血浆D二聚体（DD）、抗凝血酶活性（AT:A）、凝血酶原时间（PT）、活化部分凝血活酶时间（aPTT）、凝血酶时间（TT）、纤维蛋白原含量（Fbg）等凝血及抗凝指标。结果 DIC患儿的凝血指标与正常对照组儿童间差异有统计学意义，特别是DD含量明显增高，AT:A明显减低，差异具有显著性意义(P<0.01）；DIC发生时死亡组AT:A阳性率达100%。结论 各凝血指标特别是AT:A快速定量检测对DIC的诊断和预后评估有较高价值。
【关键词】 弥散性血管内凝血； 儿童； 凝血； 抗凝血酶活性
The Measurement of Coagulation in Children with Disseminated Intravascular Coagulation(DIC) and its Significance
YANG Rui，WEI Wenning，YANG Yan，ZHANG Zhiquan,SONG Sanjun.
（Union hospital, Tongji Medical Colledge, Huazhong University of Science and Technology，Wuhan 430022，China）
Abstract: Objective Investigate the measurement of coagulation in children with disseminated intravascular coagulation(DIC) and its significance.Methods Plasm lever of DDimer(DD),antithrombin activity(AT:A),prothrombin time(PT),activated partial thromboplastin time(aPTT),thrombin time(TT) and fibrinogen(Fbg) were tested by immunoological,color substrate and coagulation method.Results The levers of these parameters were significantly different between the DIC children and the normal children. Especially DD increased and AT:A decreased significantly(P<0.01).Sensitivities of AT:A are 100% in patient whom were died of DIC.Conclusion The fast quantitative tested of AT:A may be used for diagnosis in children with DIC and evaluation of the prognosis.
Key words: Disseminated intravascular coagulation； Child； Coagulation； Antithrombin activity
弥散性血管内凝血（DIC）是一种在多种疾病基础上发生的临床综合征，临床上表现为出血、休克、脏器功能不全等症状与体征。由于多数DIC起病急骤，发展迅速，预后凶险，因此实验室检查项目应力求简单、快速和准确。本文通过对39例DIC患儿在不同发病阶段进行多项反映凝血、抗凝血及纤溶状态的检测，探讨各项指标在DIC诊断、治疗中的价值。
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