可能是AMI的危险因素之一。并且我们推测在病理条件下,携带T等位基因的个体可促进CD14的高度表达进而增加AMI的发病风险。CD14基因启动子159C/T多态性与AMI的发病无相关性,对sCD14血清水平也无影响,认为这种基因多态性可能在AMI的发生、发展过程中不起直接的重要作用。
综上所述,AMI是一种多因素参与的常见病,遗传因素在其中起着重要作用,本研究结果提示,CD14基因启动子260C/T多态性与AMI具有一定相关性,其中T等位基因可能是AMI的遗传易感基因,携带T等位基因的个体可促进CD14的高度表达而增加AMI的发病风险。但CD14基因多态性在AMI发病中的确切机制尚不清楚,有待进一步研究和探讨。
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