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IL 21调节免疫平衡对大肠癌细胞生长的抑制作用

一条途径。

  综上,IL21能够有效调节机体的Th1/Th2平衡状态,有望在结肠癌免疫治疗方面发挥巨大作用,免疫平衡的测定和调节为结肠癌的免疫监测和免疫治疗提供了有力的工具,具有广阔的应用前景。

  【参考文献】

  1 Onishi T,Ohishi Y,Imagawa K.An assessment of the immunological environment based on intratumoral cytokine production in renal cell carcinoma〔J〕.BJU Int,1999;83(4):48892.

  2 Arrol HP,Church LD,Bacon PA,et al.Intracellular calcium signaling patterns reflect the differentiation status of human T cells〔J〕.Clin Exp Immunol,2008;153(1):8695.

  3 Wurster AL.Interleukin 21 is a T helper (Th) cell 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon gammaproducing Th1 cells〔J〕.J Exp Med,2002;196:96977.

  4 ParrishNovak J,Foster DC,Holly RD,et al.Interleukin21 and the IL21 receptor:novel effectors of NK and T cell responses〔J〕.J Leukoc Biol,2002;72:85663.

  5 张振亚,张 伟,张飞春.结肠癌细胞转染基因抑瘤效应的实验研究〔J〕.中国肿瘤临床,2005;32(1):214.

  6 Brady J,Hayakawa Y,Smyth MJ,et al.IL21 induces the functional maturation of murine NK cells〔J〕.J Immunol,2004;172:204858.

  7 Di Carlo E,Comes A,Orenqo AM,et al.IL21 induces tumor rejection by specific CTL and IFNgamma dependent CXC chemokines in syngeneic mice〔J〕.J Immunol,2004;172:15407.

  8 Reome JB,Hylind JC,Dutton RW,et al.Type 1 and type 2 tumor infiltrating effector cell subpopulations in progressive breast cancer〔J〕.Clin Immunol,2004;111(1):6981.

  9 Lamont AG,Adorini L.IL12:a key cytokine in immune regulation〔J〕. Immunol Today,1996;17(5):2147.

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