【摘要】 目的：探讨HCV感染者外周血中CD4+CD25+调节性T细胞的表达状况以及与疾病进程的相关性。方法：选取HCV感染者69例及健康对照23例，应用流式细胞术检测外周血中CD4+CD25+调节性T细胞的表达。结果：HCV感染组外周血中CD4+CD25+调节性T细胞占CD4+T细胞比例明显高于对照组(P<0.01);慢性感染组外周血CD4+CD25+调节性T细胞比例高于HCV无症状携带组(P<0.05);肝硬化组外周血CD4+CD25+调节性T细胞比例高于慢性感染组(P<0.05)。结论：HCV感染者外周血CD4+CD25+调节性T细胞水平与疾病进程具有相关性。
【关键词】 丙型肝炎病毒;CD4+CD25+调节性T细胞;疾病进程
Study on the Impact of CD4+CD25+ Regulatory T Cells on the Progression of Hepatitis C Virus Infection
SHEN Shuxu1，WU Yuhai2，GUAN Qi3，LIU Ying1
(1.Laboratory of Central Hospital of Yingkou，Yingkou 115000，China;2.Laboratory of Chinese Medicine Hospital of Lingyuan;3.Laboratory of Fengtian Hospital Affiliated to Shengyang Medical College)
AbstractObjective：To investigate the expression of peripheral blood CD4+CD25+ regulatory T cells in patients with hepatitis C and its relationship with progression of disease.Methods：Technique of flow cytometry was used to detect peripheral blood CD4+CD25+ regulatory T cells of 69 patients with Hepatitis C and 23 controls.Results：The percentage of CD4+CD25+ regulatory T cells was significantly higher in patients with hepatitis C than those in healthy controls (P<0.01).The chronic hepatitis C group had a higher percentage of CD4+CD25+ regulatory T cells than that of asymptomatic carrier (P<0.05)and the group of patients with liver cirrhosis had a higher percentage of CD4+CD25+ regulatory T cells than that of chronic hepatitis C group(P<0.05).Conclusion：Peripheral blood CD4+CD25+ regulatory T cells levels are correlated with the progression of HCV infection.
Key wordsHCV;CD4+CD25+ regulatory T cells;disease progression
丙型肝炎呈世界性分布，全球约有超过1.7亿人感染丙型肝炎病毒(HCV)，且70%～90%形成慢性感染[1]，30%发展为进展性肝病，包括肝硬化或肝癌[2];我国HCV的感染率约为3.2%[3]。研究急性自限性HCV感染患者和猩猩表明，有效控制HCV感染需要一个持久、广泛的CD4+Th细胞和细胞毒性T淋巴细胞(CTL)反应，而慢性丙型肝炎患者的HCV特异性T细胞数量减少，对抗原刺激的增生能力显著降低[4]。近来研究显示，在HCV感染中能够诱导宿主上调表达一群CD4+CD25+调节性T细胞，这类抑制性T细胞群具有免疫抑制功能，主要分泌细胞因子IL10和TGFβ，激活后的CD4+CD25+调节性T细胞能
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