|
体外肝代谢系统的研究和应用 |
| |
sp; [9]周权,姚彤炜,曾苏.手性衍生化-反相高效液相色谱法测定大鼠肝微粒体中盐酸普罗帕酮对映体及其在代谢研究中的应用[J].药学学报,2000,35(5):370.
[10]CHING M S, BICHARA N , BLAKE C L, et al. Propranonol 4 and 5hydroxylation and N desisopropylation by cloned human cytochrome P450 1A1 and P450 1A2[J].Drug Metab Dispos,1996,24(6):692.
[11]BICHARA N, CHING M S, BLAKE C L, et al. Propranolol hydroxylation and Ndesisopropylation by cytochrome P4502D6: studies using the yeastexpressed enzyme and NADPH/O2 and cumene hydroperoxidesupported reactions[J].Drug Metab Dispos,1996, 24(1):112.
[12]YOSHIMOTO K, ECHIZEN H, CHIBA K, et al. Identification of human CYP isoforms involved in the metabolism of propranolol enantiomers N desisopropylation is mediated mainly by CYP 1A2[J]. Br J Clin Pharmacol,1995,39(4):421.
[13]MASUBUCHI Y, HOSOKWA S, HORIE T, et al. Cytochrome P450 isozymes involved in propranolol metabolism in human liver microsomes. The role of CYP2D6 as ringhydroxylase and CYP1A2 as Ndesisopropylase[J].Drug Metab Dispos,1994, 22(6):909.
[14]韩聚强.体外肝细胞培养技术新进展[J].河北医科大学学报,2002,23(3):184.
[15]刘友平,丁慧荣,何涛,等.一种简单、经济、高效的大量肝细胞培养方法[J].生物学通报,2005,40(1): 47.
[16]HENGSTLER J G, UTESCH D, STEINBERG P, et al. Cryoperserved primany hepatocytes as a constantly avaible in vitro model for the evaluation of human and animal drug metabolism and enzyme induction[J]. Drug Metab Review,2000,32(1):81.
[17]NAKAGAWA Y, SUZUKI T. Metabolism of bisphenol A in isolated rat hepatocytes and oestrogenic activity of a hydroxylated metabolite in MCF7 human breast cancer cells[J]. Xenobiotica,2001,3(3):113.
[18]POTTENGER,DOMORADZKI L H,MANKHAM J Y,et al. The relative bioavilability and metabolism of bisphenol A in rats is dependent upon the route of administration[J].Toxicol Sci,2000,54(1):3.
[19]SHIBATA Y, TAKAHASHI上一页 [1] [2] [3] [4] [5] [6] 下一页
上一个医学论文： 辨治高血压病的临证体会
下一个医学论文： 亚急性甲状腺炎42例临床分析
|
|
|
您现在的位置： 绿色健康网 >> 医学论文 >> 临床医学论文 >> 正文