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米索前列醇阴道给药用于晚期妊娠促宫颈成熟的疗效探讨与护理 |
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邓六六 黄在菊
摘要 采用随机双盲临床对照试验对米索前列醇用于晚期妊娠促宫颈成熟的疗效进行了观察。将85例宫颈Bishop评分＜7分有引产指征的单胎、头位妊娠孕妇，分为试验组43例(阴道给米索前列醇100 μg)和对照组42例(给予安慰剂)。试验组用药后Bishop评分平均升高(4.4±2.2)分，明显高于对照组的(1.0±0.9)分。试验组用药后12 h内自然临产发生率为67.4%(29/43)，显著高于对照组的14.3%(6/42)。提示米索前列醇用于晚期妊娠促宫颈成熟引产安全、有效、用药方便。强调加强用药期间的观察与护理对保证治疗的成功、降低不良反应的发生有重要意义。
关键词 米索前列醇；子宫颈；晚期妊娠；护理
Observation on the Efficacy of Intravaginal Misoprostol for Cervical Ripening in the
Third Trimester of Pregnancy and Nursing Care
Deng Lulu, Huang Zaiju
Xiehe Hospital，Tongji Medical University, Wuhan 430022
Abstract A randomized, double-blind, placebo-controlled trial was conducted to evaluate the efficacy of intravaginal misoprostol for cervical ripening in the third trimester of pregnancy. Eighty-five pregnant women with indications for induction of labor and unfavorable cervices were randomly assigned to receive either intravaginal misoprostol(100 μg,n=43) as experimental group or placebo(n=42) as control group. The mean change in Bishop Score was significantly different between the two groups (4.4 for misoprostol versus 1.0 for placebo, P＜0.01). The prevalence of spontaneous onset of labor within 12 h after drug insertion in experimental group (67.4%) was obviously higher than in control group(14.3%,P＜0.05). It was suggested that intravaginal misoprostol for cervical ripening in the third trimester of pregnancy may be safe, effective and simple. It was emphasized that the intensive observation and nursing care during drug administration could be very important to assure the successful induction of labor and to reduce the side-effects of the drugs.
Key words misoprostol; cervix uteri; pregnancy trimester， third; nursing care
促宫颈成熟是晚期妊娠引产成功的关键。目前常用的促宫颈成熟药物如硫酸普拉酮、米非司酮、透明质酸酶等均需时较长、价格昂贵且应用不便。本院1994年10月至1995年9月应用米索前列醇阴道给药促宫颈成熟43例［1］，在实验观察效果良好的基础上于1995年10月至1998年7月已广泛应用于临床(280例宫颈Bishop评分＜7分者)，12 h自然临产率68.9%(193/280)。现将对照实验观察的85例报道如[1] [2] 下一页
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