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降压药物服药时间的研讨

张秀峰

摘 要:为了解决传统每日3次服药时降压效果不稳定的弊端,随机将33例高血压患者分为常药降压片;双氢克尿噻加尼群地平;心痛定加卡托普利3个组。各组均先后按每日3次,即8:00、12:00、16:00及6:00、14:00、22:00间隔8 h的两种时间服药。测量并记录每位患者6:00、8:00、10:00、16:00、18:00、20:00血压,以观察其降压效果。结果经方差分析,各时点的F值均<5.39,3组药物的疗效无显著性差异,表明疗效与药物品种无关;相同药物,同一患者,同一时点,不同时间间隔服药的收缩压、舒张压的血压值有显著性差异(t>3.169,P<0.01)。提示:8 h间隔服药,可充分利用药效学原理,改变药物效应,保持药效平稳,提高治疗效果。
关键词:降压药 服药时间

Study on the Administration time of Hypotensors

Zhang Xiufeng
(Dafeng People′s Hospital of Jiangsu Province, Dafeng 224100)

Abstract:In order to avoid the disadvantages of unstable effects of hypotensors 3 times per day, 33 patients with hypertension were randomly divided into three groups: ordinary hypotensor group, group of dihydrochlorothiazide plus, group of nifepine plus. All patients took hypotensors 3 times per day in two administrations: 8:00, 12:00, 16:00; 6:00, 14:00, 22:00 in an interval of 8 h. The blood pressure of each patient was monitored in an interval of 2 h, that was 6:00, 8:00, 10:00, 16:00, 18:00, 20:00 to observe the effects of the hypotensors. The analysis of variance showed that the F values at each time point were <5.39 with no significant difference among the three groups. It was found that the therapeutic effects were not related to the medicines. The blood pressure difference of systolic pressure and diastolic pressure at the same hypotensor, the same patient, the same time point and different time intervals for administration had a significant difference (t≥3.169,P<0.01). It was suggested that the administration of 8 h interval could pick up the hypotensor effects, maintain the stable hypotensor response and increase the therapeutic effects.
Key words:hypotensor administration time▲

  临床上在接受降压治疗的病人中,不少人早晨血压仍高,个别人且症状依旧。而下午却因血压过低而头昏、乏力,甚至发生体位性低血压。我们采用调整服药时间的方法,取得良好效果。现将观察结果报告如下。

1 临床资料

  本组33例,男26例,女7例,年龄最大84岁,最小40岁,平均61.26岁。治疗前收缩压最高29.50 kPa,最低23.00 kPa,平均24.50 kPa

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