可能通过促进细胞凋亡导致了IDD的发生。
综上所述，IGFI、IGFIR的异常表达与人IDD密切相关;IGFI、IGFIR具有促进细胞增殖、抑制细胞凋亡的作用，其异常表达可能导致IDD的发生。IGFI、IGFIR有望作为检测IDD及分子生物学治疗的指标，值得临床进一步探讨。
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