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连续服用低剂量复方炔诺酮与复方18 |
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thisterone and norgestrel, compared with the control. The mean of TG, HDL-C, ApoA1 were significantly increased simultaneously (P<0.05, P<0.01), indicated multiple effects of two low-dose Chinese COCs on lipid lipoprotein parameters. In addition, A significant increase (P<0.05) in Lp(a), an independent risk factor for cardiovascular disease, was found in norgestrel group.Further more, the results of stratified analysis to duration of contaceptives use showed that the mean of TC, LDL-C, in the combined norethisterone use less than 15 years, after the adjusting for age, were significantly lower (P<0.05, P<0.01) and the ratio of LDL-C/HDL-C was improved (P<0.05), compared with the Norgestrel; at the same time, the mean of ApoA1 was markedly higher (P<0.05) in combined norethisterone; the ratio of ApoA1/ApoB (1.87± 0.58) in the combined norethisterone group was superior to the ratio value (1.68±0.55) in norgestrel group. Conclusions These beneficial effects on lipid metabolism have been considered in dicators of potential cardiovascular protectiveeffect of the combined norethisterone for taking pill less than 15 years, but these protective effects would be reduced with adverse change in lipid and lipoprotein parameters for taking combined norethisterone more than 15 years. In contrast, the mean of TC, LDL-C, two known risk factors for cardiovascular system, in the norgestrel use less than 15 years, after the adjusting for age, were significantly increased (P<0.05, P<0.01), and adverse changes in the TC/HDL-C ratio (P<0.05) and ASI value, compared with the combined norethisterone; Lp(a) level was markedly higher in the norgestrel group than that in the control group( P<0.05). These adverse effects on lipid metabolism have been considered indicators of potential cardiovascular harmful effect of low-dose norgestrel.
【Key words】 Norethindrone； Norgestrel； Lipids
复方口服避孕药对脂代谢的影响，因避孕药所含雌激素和孕激素的种类、剂量、配位的不同而不一致上一页 [1] [2] [3] 下一页
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