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多囊卵巢综合征患者父母亲遗传表型的探讨 |
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毛文伟 李美芝 赵一鸣 陈咏健 卢春华 乔杰 王颖 王霭明 张小为
【摘要】 目的 探讨多囊卵巢综合征（PCOS）患者父母亲的遗传表型。方法 采用问卷表收集139例PCOS患者的父母亲和137名对照者父母亲的临床资料，比较母亲月经不规律、父亲早秃和父母亲高血压在两者间的发生频率，χ2检验差异显著的因素选入多因素Logistic回归模型分析。结果 PCOS患者中，母亲月经不规律者占38.1%、父亲早秃19.4%、父亲高血压30.9%，均明显高于对照者（分别为3.6%、5.1%和16.1%），差异有极显著性（P<0.01）；PCOS患者母亲高血压发生率为23.0%，高于对照者（13.9%），但差异无显著性（P=0.06）。将母亲月经不规律、父亲早秃和父亲高血压选入Logistic回归模型分析，其相对风险度(OR)均大于1（P<0.005），且各自的偏回归系数在变量不断进入模型的过程中变化不大，父亲年龄作为可能的混杂因素放入模型后，其偏回归系数非常小（P>0.05），最大似然值差值显示，3种表型致病作用的大小为：母亲月经不规律>父亲早秃>父亲高血压。结论 除母亲月经不规律和父亲早秃外，父亲高血压可能也是致女儿PCOS的独立遗传表型。
【关键词】 多囊卵巢综合征；高血压；秃发
Study on Parents Phenotypes in Women with Polycystic Ovary Syndrome
MAO Wenwei*, LI Meizhi* ZHAO Yiming, et al.
(Department of Obstetrics and Gynecology, The Third Clinical Hospital, Beijing Medical University, Beijing 100083, China)
【Abstract】 Objective To explore the parents phenotypes in women with polycystic ovary syndrome(PCOS). Methods Clinical data were collected by questionnaires from 139 parents of women with PCOS and from 137 parents of controls with normal menses. It was compared for the distribution of mother′s menses irregularity, father′s premature balding and parents hypertension by chi-square tests among parents of the PCOS group and of the controls. A multiple Logistic regression model was applied for more detailed analyses. Results The prevalences of mother′s menses irregularity, the incidence of father′s premature balding and father′s hypertension was significantly higher in PCOS group (38.1%, 19.4% and 30.9%, respectively) than in the controls (3.6%, 5.1% and 16.1%, respectively P<0.01). The prevalence of mother′s hypertension was higher in the PCOS group (23.0%) than in the controls (13.9%), but the difference was not significant (P=0.06). When mother′s menses irregularity，father′s premature balding and father′s hypertension were entered the Log[1] [2] [3] 下一页
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