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儿童糖尿病谷氨酸脱羧酶抗体水平的观察 |
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前主张联合检测胰岛细胞抗体(ICA)、酪氨酸磷酸酶样穿膜蛋白抗体以及GADab,可提高对自身免疫性糖尿病检测的阳性率。因此单一测定GADab水平还不够。尚有待测定多种抗体以进一步观察。
作者单位:200032 上海医科大学儿科医院
参考文献 1 Rowley MJ, Mackay IR, Chen QY, et al. Antibodies to glutamic acid decarboxylase discriminate major types of diabetes mellitus. Diabetes, 1992, 41:548-551. 2 Zimmet PZ, Rowley MJ, Mackay IR, et al. The ethnic distribution of antibodies to glutamic acid decarboxylase: presence and levels in IDDM in Europid and Asian subjects. J Diab Comp, 1993, 7:1-7. 3 Petersen JS. Hejnaes KR, Moody A, et al. Detection of GAD65 antibodies in diabetes and other autoimmune diseases using a simple radioligand assay. Diabetes, 1994, 43:459-467. 4 Thai AC, Ng WY, Loke KY, et al. Anti-GAD antibodies in Chinese patients with youth and adult-onset IDDM and NIDDM. Diabetologia, 1997, 40:1425-1430.
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