|
阿奇霉素治疗新生儿沙眼衣原体肺炎疗效观察 |
|
陈贻骥 周有碧 吴仕孝 刘官信 余加林
【摘要】 目的 探讨阿奇霉素治疗新生儿沙眼衣原体(Ct)肺炎的疗效。方法 15例Ct肺炎用阿奇霉素治疗,10 mg/(kg*d),每天1次连用3天,其鼻咽拭子标本用McCoy细胞培养。结果 所有病例用药后5~7天症状明显改善。3例治疗后8天重复Ct培养转阴。未发现明显胃肠道副作用,较使用红霉素等药物,疗程明显缩短,且副作用少。结论 结果表明阿奇霉素用于治疗Ct肺炎有效,新生儿对其耐受性好。 【关键词】 叠氮红霉素 衣原体,沙眼 衣原体,肺炎 婴儿,新生
The effect of azithromycin on the treatment of neonatal Chlamydia trachomatis pneumonia CHEN Yiji, ZHOU Youbi, WU Shixiao, et al. Children′s Hospital,Chongqing Medical University,Chongqing 400014 【Abstract】 Objective To investigate the effect of azithromycin on treating neonatal pneumonia caused by chlamydia trachomatis (Ct).Methods Fifteen cases of neonatal pneumonia with positive Ct in nasopharyngeal cultures were treated with azithromycin at a dose of 10 mg/(kg*d) for 3 days. Nasopharyngeal swabs of these patients were taken for the isolation of Ct in McCoy cell cultures.Results Symptoms of all patients were improved 5~7 days after azithromycin treatment. The Ct cultures became negative in 3 patients 8 days after therapy. No obvious gastrointestinal side-effects were observed. The course of azithromycin treatment was much shorter than that of erythromycin treatment and showed a few side-effects. Conclusion Azithromycin is effective in treating neonatal pneumonia caused by Ct. Neonates presented good tolerance for the treatment with azithromycin. 【Key words】 Azithromycin Chlamydia trachomatis Chlamydia pneumonia Infant,newborn
沙眼衣原体(chlamydia trachomatis,Ct)肺炎已被许多学者证实是新生儿重要疾病之一,发病率高,自然病程可持续到婴儿期,重者可造成死亡。选择敏感药物及时治疗非常重要,传统使用红霉素,但疗程长、副作用大,临床应用受到限制。本研究尝试采用阿奇霉素(azithromycin)口服,每天1次,3天为一疗程,现报道如下。
资料和方法 一、临床资料 对1997年5~7月收治的59例生后2周后发病的感染性肺炎新生儿,取鼻咽拭子标本用McCoy细胞培养、分离、鉴定,证实Ct肺炎15例,阳性率为25%(15/59),其中男9例,女6例,发病平均日龄16天(14~25天);足月儿14例,早产儿1例。3例为大于胎龄儿。剖宫产2例,余为阴道分娩。妊1产1为2例,妊2产1为4例,妊3产1为6例,妊5产1为2例,1例不详。所有病例既往均未使用大环内酯类抗生素。从发病到住院的时间平均为4天(2~13天)。15例均有气急、咳嗽13例,伴喘鸣3例,发热7例(47%)中,病初发热2例,住院期间发热5例(37.5~38.2℃),无明显呕吐腹泻症状。体检双肺呼吸音增粗11[1] [2] 下一页 上一个医学论文: 婴儿猝死综合征血中抗Ro和抗La自身抗体的检查 下一个医学论文: 抗生素对小儿呼气氢试验的影响
|
|
|
|
|
|
|