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内皮素和一氧化氮与新生儿缺氧缺血性脑病的研究 |
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张姿英 钱燕 林振浪 温怀凯
【摘要】 目的 探讨血浆与脑脊液（CSF)中内皮素（ET）、一氧化氮（NO）在新生儿缺氧缺血性脑病（HIE)中的作用及其相互关系。方法 对35例HIE患儿（轻度10例，中度13例，重度12例）分别采用放射免疫法测定血浆和CSF中ET-1，硝酸根还原酶法测定血浆和CSF中NO-2/NO-3值代表NO水平，并观察其急性期、恢复期的动态变化。设15例作为对照组。结果 急性期HIE患儿血浆和CSF中ET-1水平中、重度组明显高于对照组，尤以重度组升高显著，轻度组与对照组差异无显著意义；恢复期轻、中度组ET-1水平降至正常，但重度组仍维持在较高水平，与对照组比较，差异有显著意义。急性期HIE患儿血浆和CSF中NO水平除轻度组外，中、重度组明显高于对照组，重度组又明显高于轻度组；恢复期轻、中、重度组血浆和CSF中NO水平均降至正常，与对照组比较，差异无显著意义。结论 HIE患儿脑损伤与ET-1、NO过量合成、功能失衡有关，血浆与CSF中ET-1持续不降者提示病情严重，预后不良。
【关键词】 婴儿，新生 脑缺氧 脑缺血 内皮缩血管肽类 一氧化氮
The study of endothelin and nitric oxide levels in plasma and cerebrospinal fluid of newborn infants with hypoxic ischemic encephalopathy ZHANG Ziying, QIAN Yan, LIN Zhenlang, et al. Affiliated Children′s hospital, Wenzhou Medical College, Wenzhou 325027
【Abstract】 Objective To study the relationship and the effects of endothelin-1 (ET-1) and nitric oxide (NO) in plasma and cerebrospinal fluid (CSF) on hypoxic ischemic encephalopathy (HIE).Methods In 35 newborn infants with HIE (10 cases of mild, 13 cases of moderate and 12 cases of severe status), ET-1 levels in plasma and CSF were measured by radio immunoassay both in acute and recovery phases; NO2/NO3 level of plasma and CSF were measured with nitrate reductase.Results In acute phase, the ET-1 levels of plasma and CSF in infants with moderate and severe HIE were much higher than those in controls, especially the severe cases. There was no significant difference of ET-1 levels between the mild HIE and the control infants. However, in recovery phase, the ET-1 in severe HIE infants kept at the high level. In acute phase the NO levels in plasma and CSF of the moderate and severe HIE infants were much higher than those of the controls. The NO levels of the severe HIE infants were obviously higher than those of the mild ones. In recovery phase, the NO levels in all three groups of the HIE infants decreased to the normal levels, which were no significant differences in com[1] [2] [3] 下一页
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