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血清脂蛋白 a 与妊娠高血压综合征发病的关系 |
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赵滢 唐慧君 吕世杰 汤洁心 马悦 吴白涛
【摘要】 目的 检测妊娠高血压综合征(妊高征)患者血清中脂蛋白(a)的水平,以探讨脂蛋白(a)在妊高征发病中所起的作用。方法 应用透射比浊法检测32例妊高征患者(妊高征组)及20例正常妊娠妇女(对照组)血清中脂蛋白(a)水平,应用酶法及间接沉淀法测两组孕妇血清中胆固醇(TC),甘油三酯(TG),高密度脂蛋白胆固醇(HDL-C)的水平,应用Friedewald公式计算出低密度脂蛋白胆固醇(LDL-C)水平。 结果 (1) 妊高征组血清中脂蛋白(a)的水平[(228±187)mg/L]高于对照组[(106±93)mg/L],两组比较,差异有非常显著性(P<0.002)。(2) 妊高征组轻、中、重度患者脂蛋白(a)的水平显示:轻度患者[(109±84)mg/L]略高于对照组;中度患者[(258±230)mg/L]及重度患者[(276±166)mg/L]显著高于对照组。(3)妊高征组血清中TC,TG,LDL-C的水平分别为(6.17±1.28)mmol/L, (3.3±0.81)mmol/L和(3.71±1.32)mmol/L;对照组分别为(5.42±0.81)mmol/L,(2.78±0.88) mmol/L和(3.06±1.32)mmol/L。两组比较,差异均有显著性(P<0.05)。妊高征组HDL-C的水平为(0.98±0.16)mmol/L,低于对照组的(1.09±0.17)mmol/L。两组比较,差异有显著性(P<0.05)。结论 妊高征患者血脂蛋白(a)水平增高,并与疾病的严重程度有关,脂蛋白(a)可能参与妊高征的发病过程。 【关键词】 妊娠并发症,心血管; 高血压;脂蛋白(a)
Serum Lipoprotein(a) in Woman with Pregnancy Induced Hypertension
ZHAO Ying, TANG Huijun, LIU Shijie, et al. Department of Obstetrics and Gynecology, 2nd Affiliated Hospital, Dalian Medical University, Dalian 116001, China
【Abstract】 Objective To examine lipoprotein(a) level in woman with Pregnancy induced hypertension (PIH) to elucidate the effect of it on the pathogenesis of the disease. Methods Serum lipoprotein (a) total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) levels were measured in 20 normal pregnant woman (control group) and 32 pregnant woman with PIH (PIH group). The PIH group was further divided into the following subgroup: mild, moderate, and severe PIH. We used a transmission turbidimetry method to measure serum lipoprotein(a). Results (1) The serum lipoprotein (a)levels were higher in PIH group than that in control group (228±187 mg/L vs 106±93 mg/L). (2) The serum lipoprotein (a) levels were higher in all PIH subgroups than that in control. (3) The serum[1] [2] [3] 下一页 上一个医学论文: 血清游离绒毛膜促性腺激素 与妊娠高血压综合征发病及脏器损害的关系 下一个医学论文: 左旋门冬酰胺酶联合化疗鼻腔自然杀伤 T细胞淋巴瘤11例
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