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血清游离绒毛膜促性腺激素 与妊娠高血压综合征发病及脏器损害的关系 |
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褚红女 陈晓端
【摘要】 目的 探讨妊娠高血压综合征(妊高征)患者血清游离绒毛膜促性腺激素α亚单位(F α-hCG)水平与妊高征的严重程度及脏器损害的关系。方法 采用单克隆放射免疫法检测66例妊高征患者（妊高征组，其中轻度5例，中度8例，重度53例)；30例同期无妊高征合并症的妊娠妇女(对照组)的血清F α-hCG水平，并行尿蛋白检测。用免疫组化半定量法测定两组孕妇中各13例胎盘组织上F α-hCG的表达。结果 妊高征组F α-hCG均值为(528±421) IU/L；对照组均值为(222±129) IU/L。两组比较，差异有极显著性(P<0.001)。其中，(1) 重度妊高征患者F α-hCG水平均值为(569±455) IU/L，显著高于轻、中度患者的(363±159) IU/L；(2) 尿蛋白≥(+++)患者的血清F α-hCG水平为(598±474) IU/L， 高于尿蛋白<(+++)患者的(425±291) IU/L(P>0.05)。13例妊高征胎盘F α-hCG强阳性表达率（10/13），显著高于13例正常妊娠妇女胎盘的表达（3/13），两者比较，差异有显著性(P<0.05)。结论 妊高征患者血清F α-hCG水平显著升高，且随妊高征严重程度及脏器损伤的加重而呈高水平。血清F α-hCG升高有胎盘病理学的基础。
【关键词】 促性腺素类，绒毛膜； 妊娠并发症，心血管；高血压
A Study on the Relationship between Serum Free α-subunit of Human Chorionic Gonadotropin and Pregnancy Induced Hypertension
CHU Hongnü, CHEN Xiaoduan.
Department of Gynecology, Hospital of Obstetrics and Gynecology, Zhejiang University Medical College, Hangzhou 310006, China
【Abstract】 Objective To determine the correlation of free alpha subunit of human chorionic gonadotropin (F α-hCG) with pregnancy induced hypertension(PIH), and to observe the immunohistochemical expression of α-hCG in placentae from PIH. Methods Serum was obtained from 66 successive pregnant women diagnosed with PIH (5 mild, 8 middle and 53 severe) at 21～43 weeks′ gestation. A group of 30 non PIH gravid women were used as controls. The serum was assayed for F α-hCG by monoclonal technology and human prolactin was assayed for correcting the blood contraction. Immunolocalization and the intensity of the immunohistochemical stained in the placentae from 13 PIH and 13 nomal pregnacies. Results Significant difference was noted between the two groups mean of F α-hCG (the control group VS PIH group was 528±421 IU/L VS 222±129 IU/L, P<0.001); no significant b[1] [2] [3] 下一页
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