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放射免疫显像在恶性滋养细胞疾病诊断中的应用 |
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万希润 杨秀玉 宋鸿钊 李方 郭丽娜
【摘要】 目的 探讨放射免疫显像用于恶性滋养细胞疾病诊断的效果。方法 应用131I标记的小鼠抗人绒毛膜促性腺激素单克隆抗体，对21例恶性滋养细胞疾病患者进行24例次放射免疫显像，观察其对病灶的定位效果。结果 24例次放射免疫显像中，阳性13例次(其中假阳性1例次)，阴性11例次(其中假阴性2例次)。病灶定位的敏感性为85.7％，特异性为90.0％，准确性为87.5％。在8例手术患者中，放射免疫显像所见与病理及免疫组织化学检查结果完全相符。结论 放射免疫显像可以有效地进行恶性滋养细胞疾病病灶的定位，并具有一定的功能性诊断价值。
【关键词】 放射免疫显像 滋养层肿瘤 同位素标记
Radioimmunodetection in the Diagnosis of Trophoblastic Disease
WAN Xirun, YANG Xiuyu, SONG Hongzhao, et al.
Peking Union Hospital, Peking Union Medical College,
Chinese Academy of Medical Science， Beijing 100730
【Abstract】 Objective To study the efficiency of radioimmunodetection (RID) to locate the loci of trophoblastic disease. Method 24 RIDs were performed with 131I labeled mouse anti-hCG monoclonal antibodies on 21 patients with trophoblastic disease. Results Of 24 RIDs performed, 13 were positive, including one false positive; 11 were negative, including two false negative. The sensitivity of RID was 85.7%, the specificity was 90.0%, the accuracy was 87.5%. In 8 patients who underwent operations after RID, the findings of RID were in accordance with the pathologic and immunohistologic findings. Conclusions RID is an efficient imaging method for trophoblastic disease. In some cases, RID showed its value as a functional diagnostic method.
【Key words】 Radioimmunodetection Trophoblastic neoplasms Isotope labeling
为提高恶性滋养细胞疾病病灶定位的诊断水平，我们在应用放射免疫显像（radioimmunodetection, RID）测定，对人绒癌裸鼠皮下移植瘤成功地进行了显像观察的基础上［1］，
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