【摘要】 目的 建立一种多囊卵巢综合征(PCOS)不孕症即时促排卵方法，并观察研究该方法促排卵临床效果。方法 100例PCOS不孕症病人，分为研究组、对照组各50例。研究组入组条件：①即时激素测定雄激素正常，LH/FSH<2;②即时子宫内膜测定，厚度0.4～0.6 cm;③即时卵巢测定(超声)直径<4.0 cm。研究组病人实施即时促排卵治疗。对照组为随机的同期就诊PCOS不孕症病人，实施常规促排卵治疗，即撤退性出血第5天开始促排卵。观察两组病人第一促排卵周期中卵泡发育、排卵和妊娠等情况。结果 研究组和对照组病人成熟卵泡数、子宫内膜厚度、卵泡直径、排卵率、妊娠率分别为2.8±0.4和3.1±0.5、(1.12±0.31)和(1.09±0.28)cm、(1.81±0.35)和(1.92±0.36)cm、82.8%和84.3%、24.0%和26.0%，差异均无显著性(P>0.05)，卵巢过度刺激综合征发生率和流产率也相似。结论 即时促排卵方法治疗PCOS所致不排卵性不孕症安全、有效，与常规促排卵方法治疗PCOS的临床排卵率、妊娠率相似。
【关键词】 不育,女(雌)性;多囊卵巢综合征;排卵诱导;治疗结果
EFFICACY OF IMMEDIATE OVULATION INDUCTION FOR PATIENTS WITH POLYCYSTIC OVARY SYNDROME SHAO CUIHUA, MENG LI, QIAN JINHUA (Department of Obstetrics and Gynecology, The Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, China); [ABSTRACT] Objective To establish a new method of immediate ovulation induction (IOI) for sterile female with polycystic ovary syndrome (PCOS). Methods This study consisted of 100 infertile patients with PCOS, who were equally divided into study group and control group. The criteria of enrolment in study group were: ① immediate hormone detection, with normal androgen, and LH/FSH<2; ② immediate detection of endometrium, the thickness was 0.4-0.6 cm; ③ immediate ultrasonographic detection of ovary, with less than 4.0 cm in diameter. The patients in this group received IMI therapy, and those in control group were enrolled from outpatient sterile female with PCOS, a conventional ovulationinduction was given to them on day 5 after menses (natural or after using progesterone). The follicular development, ovulation and pregnancy in the first cycle of ovulation were observed. Results The numbers of vesicula graafianae, thickness of endometrium, follicular diameter, ovulation and pregnancy rates in study group and control group were 2.8±0.4 vs 3.1±0.5, (1.12±0.31) vs (1.09±0.28) cm, (1.81±0.35) vs (1.92±0.36) cm, 82.8% vs 84.3% and 26.0% vs 24.0%, respectively, the differences being not significant (P>
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