【摘要】 目的 探讨选择性COX2抑制剂对大鼠脊髓损伤后运动诱发电位(MEP)和后肢运动功能的影响。方法 将24只Wistar大鼠随机分为对照组和选择性COX2抑制剂组(COX2组)，每组12只。改良Allen方法致T11段脊髓不完全损伤，两组分别经尾静脉注射生理盐水0.5 mL、哌瑞昔布10 mg/kg, 分别于伤后即刻、30 min、1 h、4 h、8 h、1 d、3 d、5 d进行MEP测定, 伤后2周进行行为学检查(斜板实验+Gale评分)。结果 大鼠脊髓损伤后，COX2组MEP潜伏期延长和波幅降低的变化小于对照组(t=2.947～5.627,P<0.05); COX2组后肢运动功能的变化优于对照组(t=2.538、2.863，P<0.05)。结论 选择性COX2抑制剂能有效地阻止潜伏期的延长，明显抑制波幅的降低，并促进后肢运动功能的恢复;MEP恢复早于后肢运动功能的恢复。
【关键词】 脊髓损伤;诱发电位,运动;哌瑞昔布;运动功能
THE EFFECT OF SELECTIVE COX2 SUPPRESSANT ON MOTOR EVOKED POTENTIAL AND MOTOR FUNCTION OF HIND LIMBS IN RATS AFTER ACUTE SPINALCORD INJURY WANG KAIYOU, WANG YING, CHEN DEXI, et al (Department of Othopaedic Surgery, Haici Hospital of Qingdao, Qingdao 266033, China); [ABSTRACT] Objective To investigate the effect of Parecoxib on motor evoked potential (MEP) and motor function of posterior limbs in rats after acute spinal cord injury (SCI). Methods Twenty four Wistar rats were evenly randomized to control group and COX2 group. Modified Allen method was applied to cause incomplete SCI at T11. NS, 0.5 mL, and Parecoxib, 10 mg/kg, were separately injected through vena caudalis to the rats in two groups. MEP was detected at 30 min, 1, 4, and 8 hours and 1, 3, and 5 days after SCI. The ethology was estimated at two weeks after injury by using Gale scale. Results After SCI, extension of incubation and decline of amplitude of MEP were milder in Group COX2 than that in the control (t=2.947-5.627,P<0.05); as for the recovery of motor function, those in Group COX2 were better than those in the control group (t=2.538,2.863;P<0.05). Conclusion Parecoxib can effectively inhibit the prolong of incubation, obviously decline the amplitude and promote recovery of motor function of hind limbs. The recovery of MEP is earlier than that of hind limbs.
[KEY WORDS] Spinal cord injury; Evoked potential, motor; Parecoxib; Motor function
目前，选择性COX2抑制剂在急性脊
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