【摘要】 目的 探讨冠心病(CHD)病人血清中血管内皮细胞生长因子(VEGF)水平与幽门螺杆菌(Hp)感染情况的变化及其临床意义。方法 将经临床确诊的CHD病人60例分为稳定型心绞痛(SAP)组、不稳定型心绞痛(UAP)组、急性心肌梗死(AMI)组、陈旧性心肌梗死(OMI)组，每组各15例，以20例健康查体者作为对照组。应用ELISA法分别检测其血清VEGF水平和HpIgG表达。结果 CHD病人血清VEGF水平与HpIgG阳性率显著高于对照组(t=8.030，P<0.01;χ2=4.310，P<0.05)，SAP、UAP、AMI与OMI组病人血清VEGF水平之间两两比较，差异有显著性(F=65.01，q=3.11～18.11，P<0.05、0.01)。HpIgG阳性者血清VEGF水平显著高于阴性者(t=9.208，P<0.01)。结论 CHD病人血清VEGF与HpIgG水平显著升高，且在一定程度上反映了病情的变化，联合检测VEGF和HpIgG对预测冠心病的病变程度、判断预后有一定的价值。
【关键词】 冠状动脉疾病;血清;内皮细胞生长因子;螺杆菌感染
THE RELATIONSHIP BETWEEN SERUM LEVEL OF VEGF AND HELICOBACTER PYLORI INFECTION IN PATIENTS WITH CORONATY HEART DISEASE ZHU LINLIN, FENG JING, LIU CHENGYU (Department of Laboratory Medicine, Xinxiang Medical College, Xinxiang 453003, China); [ABSTRACT] Objective To explore the changes and clinical significance of serum levels of vascular endothelial growth factor (VEGF) and Helicobacter pyloryIgG (HpIgG) in patients with coronary heart disease (CHD). Methods Sixty CHD patients confirmed clinically were evenly divided into stable angina pectoris (SAP) group, unstable angina pectoris (UAP) group,acute myocardium infarction (AMI) group and old myocardium infarction (OMI) group. Twenty healthy people served as normal controls. Serum VEGF and HpIgG were determined by enzymelinked immunosorbent assay (ELISA). Results The serum level of VEGF and the positive rate of HpIgG in the CHD patients were significantly higher than those in the controls (t=8.030,P<0.01;χ2=4.310,P<0.05). The serum level of VEGF was significantly different among each other of SAP,UAP,AMI and OMI groups (F=65.01;q=3.11-18.11;P<0.05,0.01). The serum level of VEGF in HpIgG positive individuals was higher than that in HpIgG negative individuals (t=9.208,P<0.01). Conclusion The serum levels of VEGF and HpIgG were elevated in patients with CHD, which surely reflects the changes of the disease. A combination examination of
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