胃癌组织中增殖诱导配体及受体mRNAs表达的病理意义

【摘要】  目的：研究增殖诱导配体（APRIL）及其受体B细胞成熟抗原（BCMA）和穿膜蛋白活化物（TACI）mRNA在胃癌组织中的表达，探讨其临床病理意义。方法：收集30例胃癌及相应癌旁正常胃组织，应用RT-PCR检测APRIL及其受体mRNA在胃癌及癌旁胃组织中的表达。结果：胃癌组织APRIL mRNA阳性率（26/30，86.7%）明显高于癌旁胃正常组织（12/30，40.0%）（P＜0.01），在肠型胃癌中的表达高于弥漫型（P＜0.05），与年龄、性别、病灶大小、临床病理分期、分化程度、浸润深度、淋巴结转移等因素无关。而APRIL受体mRNA在胃癌和癌旁胃组织中表达无差异，且与年龄、性别、病灶大小、临床病理分型和分期、分化程度、浸润深度、淋巴结转移等因素无关。结论：APRIL mRNA异常表达与肠型胃癌的发生有关，检测其表达水平有助于胃癌的早期诊断。

【关键词】  胃癌；增殖诱导配体；B细胞成熟抗原；穿膜蛋白活化物

 Pathological significance of expression of a proliferation-inducing ligand

    and its receptors mRNAs in human gastric carcinoma

    1ZHANG Jianfeng，1MAO Zhenbiao，1XU Zhong，et al      （1Department of Gastroenterology， Affiliated Hospital of Nantong University， Nantong 226001; 2Department of Pathology）

    [Abstract]   Objective: To investigate the expression and clinical significance of a proliferation-inducing ligand （APRIL） and its receptors B cell maturation antigen（BCMA）， transmembrane activator and calcium modulator and cyclophilin ligand interactor protein（TACI） mRNA in gastric cancer patients. Methods: Reverse transcriptase-polymerase chain reaction （RT-PCR） was used to examine APRIL and its receptors mRNA in 30 primary gastric carcinomous tissue and the adjacent normal tissue. The expression of APRIL and its receptors mRNAs in patients with various pathological characteristucs were analyzed. Results: Positive APRIL expression was observed in 86.7% of the gastric cancer cases， while 40% in adjacent normal tissues. Significant differences in the expression of APRIL mRNA was found in adjacent normal tissues and the gastric cancer cases（P<0.01）， also showed a statistically significant difference between intestinal-type and diffuse-type gastric carcinoma（P<0.05）， while no significant differences in the expression of BCMA and TACI（P>0.05）， and no significant differences in the expression of the tumor size， differentiated subtypes， infiltrate depth， lymphatic metastases and TNM clinical stage（P>

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