糖尿病大鼠血栓调节蛋白与颈动脉病变的关系

【摘要】  目的：探讨血栓调节蛋白在糖尿病大鼠颈动脉病变中的作用。方法：Wistar大鼠48只随机分为A组24只和B组24只，B组注射链脲佐菌素制造糖尿病模型。成模后6、10和14周每组处死8只，测定颈动脉内中膜厚度、血糖、体重、血栓调节蛋白、空腹胰岛素、C肽及血脂水平。结果：随病程延长，B组空腹血糖、血栓调节蛋白、总胆固醇、甘油三酯及低密度脂蛋白显著高于A组，胰岛素、C肽及高密度脂蛋白显著低于A组；B组右颈动脉内中膜厚度在10，14周时较A组厚度明显增加；B组颈动脉内中膜厚度与血栓调节蛋白呈显著正相关。结论：糖尿病大鼠血栓调节蛋白升高与颈动脉病变显著相关，血栓调节蛋白升高先于颈动脉病理改变的发生，可能成为糖尿病颈动脉病变发生的重要早期预测指标。

【关键词】  糖尿病；血栓调节蛋白；颈动脉病变；大鼠

Study on the relationship between TM and carotid artery lesion in diabetic rats

    ZHANG Fan, DAI Qing, HE Jun      (The Third People’s Hospital of Changzhou， Changzhou 213001)

    [Abstract]   Objective: To explore the role and relationship of thrombomodulin（TM） in the development of carotid artery lesion in DM and  provide the foundation in early stage of carotid artery lesion occurred in DM. Methods: 48 Wistar rats were randomly divided into two groups. There were 24 in both groups respectively. The subjects in group B were injected with streptozotocin (50 mg/kg). After six, ten and fourteen weeks, their blood samples were obtained to measure the levels of TM，FINS，C-peptide，TG, TC, HDL and LDL, and the carotid artery intima-media thickness (IMT) was also measured.  These data were compared between two groups. Results: There were differences in the levels of FINS , C-peptide, TG, TC, HDL and LDL between group A and group B .The level of TM in group B was much higher than that in group A. The IMT of group B was higher than that of group A. Conclusion:  The increase of TM occurred before visible and measurable carotid artery pathological changes. TM could be used as an early index to predict DM carotid artery lesion.

    [Key words]   Diabetes；Thrombomodulin；Carotid artery lesion；Rat

    糖尿病心脑血管疾病发病率高，发生早、病情重，因此早期诊断、治疗十分重要。近年研究表明[1]，作为血栓前状态分子标志物的血栓调节蛋白在大血管发生动脉粥样硬化的早期就有所增加，可能在加速

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