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毛细支气管炎病后的P物质和气道反应性检测与哮喘发病关系的研究 |
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罗运春 黄达枢 方水富 陈晓芳 张正霞
【摘要】 目的 探讨毛细支气管炎与儿童哮喘的关系。方法 对50例毛细支气管炎患儿于病后5年作远期随访，应用放射免疫法测定其中30例的血浆P物质浓度，并以超声雾化蒸馏水激发试验测定气道反应性。结果 50例中有18例（36％）发展为哮喘；毛细支气管炎组血浆P物质浓度为（315±80） pmol／L，对照组30例为（234±23） pmol／L，两组相比较差异有显著意义(t′＝5.2195，P＜0.05)；超声雾化蒸馏水激发试验显示毛细支气管炎组7例阳性，而对照组全部阴性，组间差异有显著意义（P=0.00527）。结论 毛细支气管炎患儿病后哮喘的发生率达36％，部分患儿尚存在血浆P物质浓度增高和气道高反应性。
【关键词】 细支气管炎 哮喘 P物质 支气管高反应性
The relationship between substance P, airway reactivity and development of asthma after bronchiolitis
LUO Yunchun, HUANG Dashu, FANG Shuifu, et al.
Affiliated Yuying Children′s Hospital, Wenzhou Medical College, Wenzhou 325003
【Abstract】 Objective To evaluate possible relationship between substance P, airway reactivity and development of asthma after bronchiolitis. Methods Fifty cases with a history of bronchiolitis were followed up 5 years after suffering from the disease. Among them, the concentration of substance P （SP） was measured by radioimmunoassary, and the airway reactivity was evaluated by ultrasonic nebulized distilled water （UNDW） test in 30 cases and 30 healthy controls. Results Eighteen out of 50 cases （36%） developed asthma, the level of SP concentration was 315±80 pmol/L in children with a history of bronchiolitis, and 234±23 pmol/L in healthy controls（P＜0.05）. Seven out of 30 cases were positive on UNDW test and none of healthy controls was positive （P＜0.05 ）. Conclusion There were an increased morbidity of asthma, an abnormal concentration of SP in plasma and higher airway reactivity in children with a history of bronchiolitis. It is very important to prevent and monitor children with history of bronchiolitis for diagnosing and treating asthma effectively.
【Key words】 Bronchiolitis Asthma Substance P Bronchial hyper reactivity
毛细支气管炎是婴儿期最常见的病毒性呼吸道感染，其急性期有喘憋表现，在病后有明显的喘息发生。作者对50例患儿进行远期随访，并随机对其中30例进行血浆P物质（SP）和气道反应性测定，以探讨其与哮喘发病的关系。
对象和方法
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