妊娠子宫肌中促肾上腺皮质激素释放激素受体的研究

　　妊娠期与非妊娠期子宫平滑肌CRHR1α mRNA与CRHR2 mRNA表达有显著差异，提示CRHR1α mRNA、CRHR2 mRNA与妊娠关系密切。妊娠期血浆CRH的升高，正调节子宫肌组织中的CRHR蛋白表达。CRHR蛋白的表达增加抑制子宫肌中CRHR mRNA的表达。研究证明CRHR mRNA表达下降是由环磷酸腺苷-蛋白激酶A(cyclic adenosine monophosphate- protein kinase A, cAMP-PKA)旁路介导的转录后途径如mRNA降解引起的，与细胞外信号调节――丝裂原激活蛋白酶（mitogen-activated protein kinase, MAPK）旁路无关［10］。有学者提出，CRHR1对CRH的亲和力比CRHR2强，CRHR2的配体是Ucn，而不是CRH，提示CRHR2不直接调节分娩时母体血浆CRH的变化［7］。总之，CRHR1和CRH、CRHR2和Ucn及它们与妊娠、分娩启动的联系及其作用机制尚待更深一步的研究。

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