DKK 1在宫颈癌中的研究进展

　　5 问题与展望

　　最近研究表明，HPV感染是宫颈癌发生的必要条件，而经典Wnt通路的异常激活是HPV阳性患者发生宫颈癌的重要环节。研究已证实了DKK-1在诱导癌细胞凋亡、调控细胞生长等方面的作用，但就DKK-1在宫颈癌肿瘤组织中的表达及作用途径仍不明晰，需要进一步研究证实。Wnt信号通路很可能作为抗肿瘤作用的一个靶点，因此深入了解DKK-1与Wnt/β-catenin信号传导途径的特点及其在宫颈癌中的变化，对于宫颈癌的靶向治疗研究具有重要的意义。

　　【参考文献】

　　[1]Luo J, Chen J, Deng Z L, et al. Wnt signaling and human diseases: what are the therapeutic implications[J]. Lab Invest, 2007, 87(2):97-103

　　[2]Clevers H. Wnt/beta-catenin signaling in development and disease[J]. Cell, 2006, 127(3):469-480

　　[3]Irene Cappuccio I, Calderone A, Busceti CL, et al. Induction of Dickkopf-1, a Negative Modulator of the Wnt Pathway, Is Required for the Development of Ischemic Neuronal Death[J]. The Journal of Neuroscience, 2005, 25(10):2647-2657

　　[4]Glinka A, Wu W, Delius H, et al. Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction[J]. Nature， 1998, 391(6665):357-362

　　[5]Gonzalez-Sancho JM, Aguilera O, Garcia JM, et al. The Wnt an- tagonist DICKKOPF-1 gene is a downstream target of beta-cate- nin/TCF and is downregulated in human colon cancer[J]. Oncogene, 2005, 24(6):1098-1103

　　[6]Chamorro MN, Schwartz DR, Vonica A, et al. FGF-20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and development[J]. EMBO J, 2005, 24(1):73-84

　　[7]Pollheimer J, Loregger T, Sonderegger S, et al. Activation of the Canonical Wingless/T-Cell Factor Signaling Pathway Promotes Invasive Differentiation of Human Trophoblast[J]. Am J Pathol, 2006,168(4):1134-1147

　　[8]Yamabuki T, Takano A, Hayama S, et al. Dikkopf-1 as a novel serologic and prognostic biomarker for lung and esophageal carcinomas[J]. Cancer Res, 2007,67:2517-2525

　　[9]Mikheev AM, Mikheeva SA, Rostomily R, et al. Dickkopf-1 activates cell death in MDA-MB435 melanoma cells[J]. Biochem Biophys Res Co

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