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孕妇血浆中胎儿游离DNA及抗DNA抗体与子痫前期的相关性研究

fetalerythroblasts. Mol hum Reprod, 2002,8(9): 864~870.

  2 Koide K, Sekizawa A, Iwasaki M, et al. Fragmentation of cell-free fetal DNA in plasma and urine of pregnant women Prenat Diagn, 2005, 25 (7):604~607.

  3 Cuibert l,Benachi A, Grebille AG, et al. Kinetics of SRY gene appearance in maternal serum : detection by real time PCR in early pregnancy after assisted reproductive technique. Hum reprod,2003,18(8): 1733~1736.

  4 Wilson RD. Cell-free fetal DNA in the maternal circulation and its future uses obstetrics. Obstet Gynaecol Can, 2005, 27(1):54~62.

  5 Zhong XY, Laivuori H, Livingston JC, et al. .Elevation of both maternal and fetal extracellular circulating deoxyribonucleic acid concentrations in the plasma of pregnant women with preeclampsia. Am J Obstet Gynecol, 2001, 184: 414~419.

  6 Lo YMD, Leung TN, Tein MSC, et al. Quantitative abnormalities of fetal DNA in maternal serum in preeclampsia.Clin Chem, 1999,45:1884~1889.

  7 Ishihara N, Matsuo H. Increased apoptosis in the syncytiotrophoblast in human tern placentas complicated by either preeclampsia or intrauterine growth retardation. Am J Obstet Gynecol,2002, 186(1): 158~166.

  8 Sekizawa A, Jimbo M, Saito H, et al. Cell-free fetal DNA in the plasma of pregnant women with severe fetal growth restriction. Am J Obstet Gynecol, 2003, 188(2): 480~484.

  9 Lau TW, Leung TN, Chan LYS, et al. Fetal DNA clearance from maternal plasma is implied in preeclampsia. Clin Chem, 2002,48 (12): 2141~2146.

  10 Levine R J,Qian C, Leshane E S,et al. Two-stage elevation of cell-free fetal DNA in maternal sere before onset of preeclampsia. Hypertens Pregnancy, 2004,23 (3):257~268.

  11 林其德,潘家骧,金新娟. 子痫前期/子痫子宫胎盘血管床免疫病理观察. 中华妇产科杂志,1992,27(4):209~211.

  12 Hristoskova S, Holzgreve W, Hahn S. Anti-DNA antibodies are not associated with the elevated release of circulatory fetal DNA in pregnancies affected by preeclampsia. Hypertens Pregnancy, 2004, 23 (3

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