【摘要】 目的 研究子宫内膜癌组织中血管内皮生长因子C及其受体mRNA的表达情况，分析其在肿瘤转移中的作用。方法 采用RTPCR法分析48例新鲜子宫内膜癌组织标本中VEGFC/KDR/ Flt4mRNA的表达情况，并分析其与各临床病理参数之间的关系。结果 48例子宫内膜癌组织中的VEGFC及其受体mRNA表达率明显高于正常子宫内膜组织，肿瘤组织中VEGFCmRNA表达与Flt4mRNA的表达呈显著正相关。结论 VEGFC可能在子宫内膜癌转移尤其是淋巴转移中起重要作用，是一个反映病人淋巴转移和预后的良好指标。
【关键词】 血管内皮生长因子C;血管内皮生长因子受体 ;淋巴转移; 子宫内膜肿瘤
Clinicopathological significance of vascular endothelial growth factor C and its receptors in endometrial adenocarcinoma
ZHANG Hong
Central Hospital of Zibo，Zibo 255036
【Abstract】 Objective To investigate the expression of vascular endothelial growth factorC(VEGFC) and its receptor in endometrial adenocarcinoma tissue in pursuit of their role in tumor metastasis and other clinical significance.Methods 48 fresh endometrial adenocarcinoma tissue were examined by RTPCR to detect the VEGFC/KDR /Flt4mRNA expression.Results There was a significant difference of VEGFC/KDR /Flt4mRNA expression between the tumor and the normal controls. And there was no significant relationship between VEGFC mRNA, KDR mRNA or flt4mRNA expression with the pathological types and clinical stage of invasive carcinoma of cervix. But the expression was significant association with the grade of tumor pathology, lymph node metastasis, tumor size and the invasion of deep muscular layer(P<005).Conclusion The results suggest that the VEGFC may play an important role in the lymph node metastasis and it could be a useful biological marker to foresee the lymph node metastasis and prognosis for cervical cancer.
【Key words】 vascular endothelial growth factor C(VEGFC)，vascular endothelial growth factor receptor，lymphatic metastasis，cervical neoplasm
子宫内膜癌是严重威胁妇女生命的第三大恶性肿瘤，发病率呈升高和低龄化趋势。目前子宫内膜癌的发病原因及机制尚未完全阐明，诊断治疗上还有许多问题没有解决。其发生远处转移是造成子宫内膜癌治疗困难的原因之一，多数学者认为淋巴结转移对子宫内膜癌的预后至关重要，是判断患者预后和确定治疗方案的重要依据。目前的仪器检查很难较早发现淋巴结转移，淋巴结转移是子宫内膜癌治疗的难点之一，而对其淋巴道转移机制的深入研究将有助于新的有效的治疗手段的发展。由于缺乏明确的淋巴管生成因子和标记因子，对淋巴转移的研究进展缓慢。血管内皮生长因子C(vascular endothelial growth factor C
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