【摘要】 目的观察不同浓度大蒜素对卵巢癌化疗中顺铂副反应的影响。方法将我院2005年3月—2007年12月间，120例卵巢癌顺铂化疗患者，随机分成两组：A组(60例)，给予大蒜素10 mg/kg 静脉输注;B组(60例)，给予大蒜素40 mg/kg 静脉输注。比较化疗后患者副反应发生情况。结果两组年龄、体重、化疗次数比较，差异无统计学意义( P> 0.05)。B组化疗后胃肠道反应、肾毒性等并发症的发生率明显低于A组(P<0.05)。结论静脉输注40 mg/kg 大蒜素可减轻卵巢癌化疗中顺铂的副反应。
【关键词】 卵巢肿瘤 化疗 顺铂 大蒜素
Effect of Allactin at Various Concentrations on Reduction of Side Reaction Caused by Cisplatinum during Ovarial Cancer Treatment
Liu Xiumei
Qinhuangdao Maternity and Children s Hospital, Qinhuangdao 066000, China
Abstract： ObjectiveTo investigate the effect of allactin at different concentrations on reduction of the side reaction resulting from cis-platinum during ovarial cancer treatment. MethodsFrom March 2005 to December 2007, 120 patients with ovarial cancer of our department who would receive cisdiaminodichloroplatinum treatment were classified randomly into two groups. Group A (n=60) was administered with allactin by intravenous infusion at 10 mg/kg, and Group B (n=60) with allactin for intravenous infusion at 40 mg/kg. The incidence of the side reaction was compared. ResultsThere were not significancely differences in age, body weight and chemotherapeutic frequence between the two groups (P>0.05). The incidences of gastrointestinal response and renal toxicity were significantly lower in Group B than in Group A (P<0.05).ConclusionAllactin for intravenous infusion at 40mg/kg may induce side reaction of cisplatin in ovarial cancer treatment.
Key words： ovarial; chemotherapy; cisplatin; allactin
顺铂(DDP)作为治疗肿瘤的首选化疗药物之一，对卵巢癌的疗效是肯定的。肿瘤化疗失败的主要原因是严重的副作用及肿瘤对化疗药物产生耐药反应。理想的化疗应是最大限度地杀伤肿瘤细胞，同时对正常细胞的毒性最低。大蒜素是具有多种生物活性的化合物，具有抗癌作用[1]，对顺铂有增敏作用，并能减轻顺铂所致的肾毒性。本研究旨在通过临床观察，探讨不同剂量大蒜素对卵巢癌化疗中顺铂副反应的影响，以期寻求更有效的对卵巢癌的治疗方法。
1材料与方法
1.1一般资料
2005年3月—2007年12月我院120例卵巢癌顺铂化疗患者，随机分成两组：A组60例，平均年龄为(49.3±5.7) 岁，平均体重为(52±6) kg，平均化疗次数(3±1)次，给予大蒜素10 mg/kg 静脉输注;B组60例，平均年龄为(48.9±6.1) 岁，平均体重为(53±1) kg，平均化疗次数(3±1)次，给予大蒜素40
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