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IL 8 mRNA在分娩期宫颈扩张过程中子宫下段肌层表达意义

可以通过趋动中性粒细胞,并使中性粒细胞降解、释放胶原酶,在宫颈扩张过程中起作用。本研究结果亦为宫颈扩张过程类似急性炎症反应的学说进一步提供了依据。
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  【参考文献】

  [1] Thomson AJ,Telfer JF,Young A,et al.Leukocyte density and pro-inflammatory cytokine expression in human fetal membranes,decidua,cervix and myometrium before and during labour at term[J].Hum Reprod,1999,14(1):229-236.

  [2] Kemp B,Menon R,Fortunato SJ,et al.Quantitation and localization of inflammatory cytokines interleukin-6 and interleukin-8 in the lower uterine segment during cervical dilatation[J].J Assist Reprod Genet,2002,19(5):215-219.

  [3]Pijnenborg R,McLaughlin PJ,Vercruysse L,et al.Immunolocalization of tumour necrosis factor-alpha (TNF-alpha) in the placental bed of normotensive and hypertensive human pregnancies[J].Placenta,1998,19(4):231-239.

  [4]Sehringer B,Schafer WR,Wetzka B,et al.Formation of proinflammatory cytokines in human term myometrium is stimulated by lipopolysaccharide but not by corticotropin-releasing hormone[J].J Clin Endocrinol Metab,2000,85(12):4 859-4 865.

  [5] Osman I,Young A,Ledingham MA,et al.Leukocyte density and pro-inflammatory cytokine expression in human fetal membranes,decidua, cervix and myometrium before and during labour at term[J].Mol Hum Reprod,2003,9(1):41-45.

  [6] Maul H,Nagel S,Welsch G,et al.Messenger ribonucleic acid levels of interleukin-1 beta,interleukin-6 and interleukin-8 in the lower uterine segment increased significantly at final cervical dilatation during term parturition,while those of tumor necrosis factor alpha remained unchanged[J].Eur J Obstet Gynecol Reprod Biol,2002,102(2):143-147.

  [7] Winkler M,Rath W.Changes in the cervical extracellular matrix during pregnancy and parturition[J].J Perinat Med,1999,27(1):45-60.
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